6-Gingerol, an active ingredient of ginger, reshapes gut microbiota and serum metabolites in HFD-induced obese mice

Alhamoud, Yasmin; Ijaz Ahmad, Muhammad; Abudumijiti, Tuerxunayi; Wu, Junhao; Zhao, Minjie; Feng, Fengqin; Wang, Jing

doi:10.1016/j.jff.2023.105783

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…Ginger is also known for its microbe-modulating effects. In an obese mouse model induced by a high-fat diet, 6-gingerol, a bioactive compound of ginger, was shown to reshape the composition of the gut microbiota by increasing the abundance of weight-loss-associated genera (e.g., Muribaculaceae , Alloprevotella , and Akkermansiaand ) and decreasing the abundance of obesity-contributed bacteria (e.g., Lachnospiraceae and Lactobacillus reuteri ) [ 253 ]. Moreover, the effect of ginger-root powder was tested in healthy adults in a double-blind placebo-controlled trial, showing that while supplementation with ginger root powder induced changes in the gut microbiota composition, it did not change the microbial diversity, bowel function, gastrointestinal symptoms, mood, or quality of life [ 254 ].…”

Section: Ingredients For Functional Foods and Beverages With Promisin...mentioning

confidence: 99%

Local and Systemic Effects of Bioactive Food Ingredients: Is There a Role for Functional Foods to Prime the Gut for Resilience?

Jacquier,

van de Wouw,

Nekrasov

et al. 2024

Foods

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Scientific advancements in understanding the impact of bioactive components in foods on the gut microbiota and wider physiology create opportunities for designing targeted functional foods. The selection of bioactive ingredients with potential local or systemic effects holds promise for influencing overall well-being. An abundance of studies demonstrate that gut microbiota show compositional changes that correlate age and disease. However, navigating this field, especially for non-experts, remains challenging, given the abundance of bioactive ingredients with varying levels of scientific substantiation. This narrative review addresses the current knowledge on the potential impact of the gut microbiota on host health, emphasizing gut microbiota resilience. It explores evidence related to the extensive gut health benefits of popular dietary components and bioactive ingredients, such as phytochemicals, fermented greens, fibres, prebiotics, probiotics, and postbiotics. Importantly, this review distinguishes between the potential local and systemic effects of both popular and emerging ingredients. Additionally, it highlights how dietary hormesis promotes gut microbiota resilience, fostering better adaptation to stress—a hallmark of health. By integrating examples of bioactives, this review provides insights to guide the design of evidence-based functional foods aimed at priming the gut for resilience.

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Section: Ingredients For Functional Foods and Beverages With Promisin...mentioning

confidence: 99%

Local and Systemic Effects of Bioactive Food Ingredients: Is There a Role for Functional Foods to Prime the Gut for Resilience?

Jacquier,

van de Wouw,

Nekrasov

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

Low molecular weight polysaccharide of Tremella fuciformis exhibits stronger antioxidant and immunomodulatory activities than high molecular weight polysaccharide

Lee,

Xue,

Luo

et al. 2024

International Journal of Biological Macromolecules

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Gut microbiota-derived metabolites: implications for metabolic syndrome and therapeutic interventions

Olalekan,

Bakare,

Osonuga

et al. 2024

Egypt J Intern Med

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Background The gut microbiota (GM) and their metabolites have garnered significant attention for their roles in metabolic syndrome (MetS) and associated conditions. MetS, characterized by a cluster of metabolic abnormalities, significantly increases the risk of cardiovascular disease (CVD), obesity, insulin resistance, and type 2 diabetes mellitus (T2DM). The dysbiosis of gut microbiota, marked by changes in microbial composition and function, has been implicated in the pathogenesis of MetS. Main body This review synthesizes recent findings elucidating the influence of GM composition and microbiota-derived metabolites on MetS pathogenesis and progression. Notably, alterations in GM composition and dysregulation of metabolites such as short-chain fatty acids (SCFAs), trimethylamine N-oxide (TMAO), polyamines, amino acids, and indole derivatives have been implicated in MetS development. These metabolites play crucial roles in metabolic processes, and their imbalance can trigger or exacerbate metabolic disturbances associated with MetS. Various therapeutic approaches, including dietary interventions, probiotics, prebiotics, and precision medicine targeting specific metabolites, offer promising strategies for managing MetS. These interventions aim to restore a healthy GM balance and regulate the production of beneficial metabolites. Conclusion The complexity of GM interactions and their systemic effects necessitate more standardized research methodologies. Future investigations focusing on personalized therapeutic interventions and non-invasive diagnostic tools are warranted to address the complexities of MetS management. Advancing our understanding of the GM-metabolite-MetS axis will be crucial for developing effective, targeted treatments and improving patient outcomes in MetS.

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6-Gingerol, an active ingredient of ginger, reshapes gut microbiota and serum metabolites in HFD-induced obese mice

Cited by 5 publications

References 54 publications

Local and Systemic Effects of Bioactive Food Ingredients: Is There a Role for Functional Foods to Prime the Gut for Resilience?

Local and Systemic Effects of Bioactive Food Ingredients: Is There a Role for Functional Foods to Prime the Gut for Resilience?

Low molecular weight polysaccharide of Tremella fuciformis exhibits stronger antioxidant and immunomodulatory activities than high molecular weight polysaccharide

Gut microbiota-derived metabolites: implications for metabolic syndrome and therapeutic interventions

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