Gut microbiota-derived metabolites: implications for metabolic syndrome and therapeutic interventions
Samuel Oluwadare Olalekan,
Olalekan Olanrewaju Bakare,
Ifabunmi Oduyemi Osonuga
et al.
Abstract:Background
The gut microbiota (GM) and their metabolites have garnered significant attention for their roles in metabolic syndrome (MetS) and associated conditions. MetS, characterized by a cluster of metabolic abnormalities, significantly increases the risk of cardiovascular disease (CVD), obesity, insulin resistance, and type 2 diabetes mellitus (T2DM). The dysbiosis of gut microbiota, marked by changes in microbial composition and function, has been implicated in the pathogenesis of MetS.
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