6-Aminoalkyloxazolo[4,5-b]pyridin-2(3H)-ones: Synthesis and Evaluation of Antinoceptive Activity

<b>Synthesis, characterization and X-ray structure of an oxazine derivative</b>

“…The chemistry of oxazine derivative compounds is the subjects of growing interest [1][2][3][4]. Many of these compounds are relevant to the biochemistry of enzymes [5] and cytotoxic drugs [6].…”

Hydrogen‐Bond‐Directed Catalysis: Faster, Regioselective and Cleaner Heck Arylation of Electron‐Rich Olefins in Alcohols

“…These methods have significantly extended the utility of the Heck reaction and led to a number of interesting applications in chemical synthesis. [6][7][8][9] However, there are short comings associated with the methods: silver introduces added cost, thallium salts are toxic and triflates are generalAbstract: A general method for the regioselective Heck reaction of electronrich olefins is presented. Fast, highly regioselective Pd-catalysed a-arylation of electron-rich olefins, vinyl ethers (1 a-d), hydroxyl vinyl ethers (1 e, f), enamides (1 g, h) and a substituted vinyl ether (1 i) has been accomplished with a diverse range of aryl bromides (2 a-r), for the first time, in cheap, green and easily available alcohols with no need for any halide scavengers or salt additives.…”

Synthesis of Novel Oxazolo[4,5‐b]pyridine‐2‐one based 1,2,3‐triazoles as Glycogen Synthase Kinase‐3β Inhibitors with Anti‐inflammatory Potential

“…In continuation to the work performed by our group on benzoxazolinone and 2‐mercaptobenzoxazole‐based 1,2,3‐triazole conjugates as anti‐inflammatory compounds , we extended our studies to oxazolo[4,5‐b]pyridine‐2‐one moiety, the bio‐isostere of benzoxazolinone and 2‐mercaptobenzoxazole. Oxazolopyridinones have been reported to be pharmaceutically important as anti‐nociceptive, anti‐inflammatory, anti‐malarial, and Met kinase inhibitors . Recently, oxazolo‐pyridines have also been reported as potent GSK‐3 β inhibitors .…”