<b>Synthesis, characterization and X-ray structure of an oxazine derivative</b>

Abstract

The 5,6-dihydro-6-methyl-2,3-diphenyl-2H-1,4-oxazine-2-ol compound (2) was prepared unambiguously by condensation of 1,2-diphenylethanone with 1-amino-2-propanol in the presence of glacial acetic acid. The product was characterized by FT-IR, 1 HNMR, UV-Vis spectroscopy and X-ray crystallography. Quantum chemical calculations are used to the proposed mechanism.

In(OTf)3-catalyzed tandem aza-Piancatelli rearrangement/Michael reaction for the synthesis of 3,4-dihydro-2H-benzo[b][1,4]thiazine and oxazine derivatives

“…In addition a v-coupling, 4 J H3-H2(pro-S) = 1. 6 Hz, and nOe correlation between H5/H6 further supports the structure. An energy minimized structure 14 is consistent with the NMR findings which are given in Fig.…”

“…1 They are known to display aldose reductase inhibitory activity 2 and potential therapeutic properties. 3 In addition to this, benzoxazinones exhibit a diverse range of pharmacological properties such as anti-candidaalbicans, 4 antifungal, 5 kinase inhibitory, 6 antagonism to progesterone receptor, antitumor, antiviral, antithrombotic, antimycobacterial, anti-inflammatory, antidiabetic and hypolipidaemic effects. 7 Furthermore, 2-arylidene-4-aminoalkyl-2H-1,4-benoxazin-(4H)-ones and related compounds were found to exhibit significant CNS (central nervous system) depression.…”

Synthesis, Characterization, and Structure of Some 1,4‐Disubstituted Cyclopenta[d][1,2]oxazines

“…). Oxazines that contain aromatic fragments or a fused cyclopentadienyl ring are well known and possess a wide variety of novel medicinal applications . For example, cyclopenta[ d ][1,2] fused‐ring oxazines (Fig.…”