5HT2A receptor gene and bipolar affective disorder

Gutiérrez, Blanca; Arranz, Maria; Fañanás, Lourdes; Vallès, Vicenç; Guillamat, Roser; Os, Jim van; Collier, David

doi:10.1016/s0140-6736(95)91590-7

Cited by 36 publications

(13 citation statements)

References 2 publications

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“…This is in accordance with previous association studies between 5-HT2a and bipolar disorder [25,26] as well as between DRD2, DRD3 and DAT1 and bipolar disorder [27][28][29][30]. These results may indicate that in our Austrian sample, these polymorphisms are unlikely to play a major role in genetic susceptibility for bipolar disorder.…”

Section: Discussionsupporting

confidence: 93%

Association Studies of Candidate Genes in Bipolar Disorders

Heiden

Schüssler²,

Itzlinger³

et al. 2000

Neuropsychobiology

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The aim of the investigation was to test genes for predisposition to bipolar affective disorder. Therefore, we studied candidate genes in a sample of unrelated patients (n = 102) and healthy controls (n = 79) of Austrian origin, searching for a possible association between polymorphic DNA markers of 5 candidate genes (serotonin transporter, 5-HTT; serotonin 2a receptor, 5-HT2a; dopamine D2 receptor, DRD2; dopamine D3 receptor, DRD3; dopamine transporter, DAT1) and bipolar disorder. There was an association between allelic and genotypic frequencies of 5-HTT and affection status (p = 0.014 and p = 0.017, respectively). However, after correction for multiple comparisons (Bonferroni), these results did not remain significant. Nevertheless, the findings might suggest that alterations in the structure of 5-HTT are involved in the pathogenesis of bipolar disorder, which could have major implications in treatment. No association between 5-HT2a, DRD2, DRD3, DAT1 and bipolar disorder was found.

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Section: Discussionsupporting

confidence: 93%

Association Studies of Candidate Genes in Bipolar Disorders

Heiden

Schüssler²,

Itzlinger³

et al. 2000

Neuropsychobiology

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“…This negative finding is consistent with previous association studies suggesting that the 5HT 2A R gene is unlikely to play a major role in genetic susceptibility to BPAD [Gutierrez et al, 1995[Gutierrez et al, , 1997Arranz et al, 1997;Mahieu et al, 1997;Zhang et al, 1997;Ohara et al, 1998;Tsai et al, 1999;Blairy et al, 2000;Massat et al, 2000;Tut et al, 2000;Murphy et al, 2001]. A large sample would be required to exclude a minor effect.…”

Section: Discussionsupporting

confidence: 91%

“…Most studies detected no association in Caucasian [Gutierrez et al, 1995[Gutierrez et al, , 1997Arranz et al, 1997;Mahieu et al, 1997;Blairy et al, 2000;Massat et al, 2000;Murphy et al, 2001] and Asian populations [Zhang et al, 1997;Ohara et al, 1998;Tsai et al, 1999;Tut et al, 2000]. Two studies reported an association between BPAD and the 5HT 2A R gene, using the À1438G/A [Chee et al, 2001] and À102T/C polymorphisms [Vincent et al, 1999].…”

Section: Introductionmentioning

confidence: 99%

Lack of association between 5HT_2A receptor gene haplotype, bipolar disorder and its clinical subtypes in a West European sample

Étain

Rousseva

Roy

et al. 2004

American J of Med Genetics Pt B

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Bipolar affective disorder (BPAD) is a complex psychiatric disorder with a major genetic contribution. Abnormalities in serotonergic function have been implicated in its aetiology. The 5HT2A receptor (5HT2AR) gene is a strong candidate gene for involvement in BPAD, but previous association studies have reported conflicting results. These data are difficult to interpret because most negative results were obtained with small samples. The aim of this study was to test the association between the 5HT2AR gene and BPAD in a large West European sample. We studied the -1438G/A and the His452Tyr polymorphisms, for haplotype analysis to increase both informativity and the likelihood of detecting an association between BPAD and the 5HT2AR gene. We analysed the genotype, allele and haplotype distributions of two 5HT2AR gene variants in a population of 356 BPAD patients, which we compared with 208 healthy controls. We also carried out exploratory analysis in clinical subgroups of patients defined according to personal history of mood disorders, suicidal behaviour, comorbid psychiatric disorders and family history of affective disorders. We found no difference between BPAD patients and controls for allele, genotype and haplotype distributions. Exploratory analysis in subgroups of BPAD patients showed only a marginal difference in haplotype distribution between controls and BPAD patients with antidepressant-induced mania (P = 0.018). This difference was not significant after correction for multiple testing. Our study suggests that the 5HT2AR gene is unlikely to be involved in genetic susceptibility to BPAD but should be further investigated in a pharmacogenetic study.

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“…Although this study is the first to examine the gene within puerperal psychosis, these findings are consistent with the majority of literature on 5HT2A and BP. A number of association studies have studied the polymorphism and BP with no significant associations reported (25–28). Positive findings have been reported at this polymorphism in studies of depression (29) and suicidal ideation (29).…”

Section: Discussionmentioning

confidence: 99%