574 Jejunal Absorption of Short and Long Chain Glucose Oligomers (Go) in the Absence of Pancreatic Amylase Pa)

Kerzner, Benny; Sloan, Howard R.; McClung, H J; Chidi, Christopher C.

doi:10.1203/00006450-198104001-00587

Cited by 5 publications

(2 citation statements)

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“…The results of this study clearly demonstrate that replacement of glucose with glucose polymer s in the oral rehydration solution does not offer any added advantages with regard to decre asing the duration and severity of diarrhea. These result s are in contradiction with results from studies conducted in animals (10,11) and clinical trials conducted in infants with diarrhea (12), which suggested that maltodextrinbased DRS might be superior to standard glucosebased ORS, although the earlier study was conducted in infants with more evidence of intestinal damage. It should be underlined that these studies were not randomized and not double-blind, and their results are therefore difficult to interpret.…”

Section: Discussioncontrasting

confidence: 62%

A Randomized Double‐Blind Clinical Trial of a Maltodextrin‐Containing Oral Rehydration Solution in Acute Infantile Diarrhea

Santos Ocampo,

Bravo,

Rogacion

et al. 1993

J. pediatr. gastroenterol. nutr.

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SummaryA double‐blind, randomized controlled study was used to compare the efficacy and safety of an oral rehydration solution either with minimally hydrolyzed maltodextrins or the standard recommended glucose. One hundred twenty pediatric patients with acute watery diarrhea (60 in each group) were studied, but only 116 patients were included in the final analysis. After rehydration, outcome variables did not differ significantly at p < 0.05. Mean duration of diarrhea was 52.5 ± 32.2 h for the control group (median, 50.8 h) and 57.2 ± hours for the study group (median, 45.3 hours). Comparisons of the mean stool output, weight gain, and ORS intake on the 24th h and from admission to discharge were not statistically significant. Differences in laboratory parameters consisting of mean serum sodium, potassium, total C02, hematocrit, plasma total solids, urine specific gravity, and random blood sugar were likewise not significant. Differences in stool pH and reducing sugars were statistically significant; however, the observed values were still within normal range. All laboratory values improved upon rehydration. Replacement of glucose with maltodextrins did not offer added advantages in reducing the duration and severity of diarrhea.

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Section: Discussioncontrasting

confidence: 62%

A Randomized Double‐Blind Clinical Trial of a Maltodextrin‐Containing Oral Rehydration Solution in Acute Infantile Diarrhea

Santos Ocampo,

Bravo,

Rogacion

et al. 1993

J. pediatr. gastroenterol. nutr.

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“…They investigated jejunal utilization of glucose and glucose oligomers in the absence of pancreatic secretion and noted greater carbohydrate absorption from glucose than from oligomer solutions. A subsequent study by the same investigators with a similar experimental model demonstrated that sucrose digestion exceeded that of polymeric glucose (15). Lifschitz et al (16) studied peak breath hydrogen levels in 28 infants hospitalized for diarrhea.…”

Section: Discussionmentioning

confidence: 97%

Dietary Fructose in the Management of Intractable Diarrhea of Infancy

Clark,

Bullock,

Fitzgerald

1986

J. pediatr. gastroenterol. nutr.

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SummaryCarbohydrate digestion/absorption was evaluated in 11 infants with intractable diarrhea while they were receiving a carbohydrate‐free soy‐isolate formula. Seven patients were fed within 48 h of admission. Enteral feedings were initiated in the remainder after they had gained 1 kg while receiving parenteral nutrition. All feedings were initially administered by continuous nasogastric infusion. Nine patients were initially fed formula with polymeric glucose; two received fructose as the carbohydrate source, based on a documented history of polymeric glucose intolerance. Five of the nine developed watery, acidic stools while receiving polymeric glucose. All were switched to fructose, which resulted in improvement in stool pH and consistency. Glucose tolerance was normal 1 month after discharge in all seven fructose‐requiring infants. Three of six infants have shown a persistent inability to hydrolyze sucrose. Several putative mechanisms of polymeric glucose intolerance are discussed, as well as the apparent association with primary sucrase‐isomaltase deficiency in three of the patients. Fructose is an effective alternative carbohydrate source in infants unable to tolerate polymeric glucose, and early initiation of fructose may obviate the need for total parenteral nutrition and prolonged bowel rest.

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