532 nm Pulsed Potassium‐Titanyl‐Phosphate Laser Treatment of Laryngeal Papillomatosis under General Anesthesia

Burns, James A.; Zeitels, Steven M.; Akst, Lee M.; Broadhurst, Matthew S.; Hillman, Robert E.; Anderson, R. Rox

doi:10.1097/mlg.0b013e318064e869

Cited by 70 publications

(65 citation statements)

References 15 publications

(34 reference statements)

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“…Various other studies also suggest CO 2 laser to be the mainstay of treatment. [19] Cold instruments were method of choice in past and are still used in certain centers. Recently, some studies also suggest use of microdebrider and report them to be superior to laser surgery.…”

Section: Discussionmentioning

confidence: 99%

Remission in juvenile-onset recurrent respiratory papillomatosis

Gandhi

Jacob

2012

J Laryngol Voice

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Section: Discussionmentioning

confidence: 99%

Remission in juvenile-onset recurrent respiratory papillomatosis

Gandhi

Jacob

2012

J Laryngol Voice

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“…Originally used in continuous mode, it was found to be most useful in treating subglottic hemangiomas, vocal fold ectasias, and varices (18). The KTP laser has a wavelength of 532 nm, which hemoglobin absorbs more strongly than the 585 nm wavelength of the PDL (47,48). The wider pulse width of the KTP is its principle advantage, as it is able to spread laser energy over a longer time period, thus offering slower heating and more even coagulation (47–49).…”

Section: Comparing Types Of Lasersmentioning

confidence: 99%

Use of Lasers in Laryngeal Surgery

et al. 2010

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Lasers are a relatively recent addition to laryngeal surgery. Since their invention, laser use and applications have expanded rapidly. In this paper, we discuss the benefits and disadvantages of lasers for different procedures, as well as ways to overcome commonly faced clinical problems. The use of lasers in surgery has offered a time- and cost-efficient alternative to cold surgical techniques, and has been employed in the treatment of numerous laryngeal pathologies, including stenoses, recurrent respiratory papillomatosis, leukoplakia, nodules, malignant laryngeal disease, and polypoid degeneration (Reinke’s edema). However, lasers can incur adjacent tissue damage and vocal fold scarring. These problems can be minimized through understanding the mechanisms by which lasers function and correctly manipulating the parameters under a surgeon’s control. By varying fluence, power density, and pulsation, tissue damage can be decreased and lasers can be used with greater confidence. The various types of lasers and their applications to the treatment of specific pathologies are reviewed with the intention of helping surgeons select the best tool for a given procedure. Recent applications of lasers to treat benign laryngeal lesions and severe laryngomalacia demonstrate that additional research must be conducted in order to realize the full potential of this surgical tool.

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“…Photoangiolysis of the microcirculation within the layered microstructure (superficial lamina propria and epithelium) of the phonatory mucosa has been shown to be an effective strategy to treat a number of lesions including papillomatosis [13][14][15][16][17] , dysplasia [18][19][20][21] , and microvascular angiomata. [22][23][24] While the 532nm wavelength of the KTP laser is slightly more absorbed by oxyhemoglobin than the 585nm wavelength of the PDL (Figure 1A), this is not clinically significant and the selective optical penetration/absorption in blood vessels and surrounding tissues is similar for each laser.…”

Section: Photoangiolytic Lasers: Ktp and Pdlmentioning

confidence: 99%

Innovative laser based approaches to laryngeal cancer: what an engineer and physicist need to know

Burns

2008

SPIE Proceedings

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Innovative laser-based approaches to laryngeal cancer include the clinical applications of two new technologies, photoangiolysis using a 532nm wavelength pulsed-KTP laser and fiber-based cutting using a 2µm wavelength thulium laser. Photoangiolysis is well-suited for treatment of minimally invasive glottic cancer and allows maximum preservation of phonatory surfaces needed for optimal voicing. The thulium laser offers an alternative to the carbon dioxide laser as an endolaryngeal cutting tool due to its enhanced hemostatic properties and fiber-based delivery. Clinical examples of pulsed-KTP laser involution of early glottic cancer will be presented in order to highlight the concept of targeting tumor angiogenesis in treating laryngeal cancer. The surgical experience using the thulium laser for complex endoscopic endolaryngeal excisions of large laryngeal cancers is presented to demonstrate the expanded clinical applications of endolaryngeal cutting offered by this laser. The laryngeal tissue effects of various laser power and pulse width (PW) settings, mode of delivery, active cooling to reduce thermal trauma, and wavelength selection have been extensively studied for the KTP and thulium lasers in both ex-vivo and liveperfusing models. The results from these studies, included herein, determine the clinical efficacy and safety of these innovative laser-based approaches to laryngeal cancer.

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532 nm Pulsed Potassium‐Titanyl‐Phosphate Laser Treatment of Laryngeal Papillomatosis under General Anesthesia

Abstract: The 532 nm pulsed-KTP laser was effective for treating recurrent respiratory papillomatosis, which was similar to our experience as an office-based procedure.

Cited by 70 publications

References 15 publications

Remission in juvenile-onset recurrent respiratory papillomatosis

Remission in juvenile-onset recurrent respiratory papillomatosis

Use of Lasers in Laryngeal Surgery

Innovative laser based approaches to laryngeal cancer: what an engineer and physicist need to know

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