53 The kiel experience in PDR interstitial and intracavitary brachytherapy

Feasibility of Combined Operation and Perioperative Intensity-Modulated Brachytherapy of Advanced/Recurrent Malignancies Involving the Skull Base

“…The motivation for developing this therapeutic approach was the desire to elaborate an interdisciplinary method which is effective in gaining local tumor control but one which, at the same time, allows for the preservation of visual acuity also in patients who have undergone previous therapeutic irradiation. Early results from patients with orbital malignancies which have been treated with this method by our interdisciplinary team have been encouraging [17][18][19][20]. The aim of this retrospective analysis was to assess the technical feasibility and toxicity involved in this method and to evaluate the outcomes of patients who have received such treatments -with a particular emphasis on the posttreatment intactness of their visual systems.…”

Radiosensitizing Effect of Carbogen Breathing during Pulsed Irradiation of the Rat R1H Tumor

“…In a typical clinical pulsed irradiation protocol, a boost dose or a full irradiation course is applied day and night continuously with a dose per pulse between 0.5 and 1 Gy, separated by irradiationfree time intervals of approximately one hour (1). For radiation safety and logistic reasons, some institutes do not irradiate during the night and restrict the irradiation course to 'of ce hours' (2,3). Pulsed irradiation offers new possibilities for conformal radiotherapy by selection of the dwell positions and dwell times of the radioactive source.…”