5‐year experience of a tertiary center in major congenital abnormalities in singleton pregnancies

Abstract

Objective: To demonstrate major congenital abnormalities delivered or terminated at our institution between 2014 and 2018.Materials and Methods: Necessary information was retrieved from the registries of the delivery room and electronic database of Hacettepe University Hospital, Ankara. Results: This study was consisted of 307 major congenital anomalies. The incidence of major congenital anomalies was 2.9 per 1,000 live births, while the majority of the cases were related to cardiovascular, central nervous system, and diaphragmatic hernia with 97, 87, and 25 cases at each group, respectively.Rate of termination of pregnancy (TOP) and live birth were 35.1 and 59.2%, respectively. The overall infant mortality rate was 28.9% in cases with live birth, while this rate was highest in cardiovascular system abnormalities and diaphragmatic hernia. Out of 182 newborns, 92.8% admitted to the neonatal intensive care unit after the delivery. Median gestational week at TOP was 21(20). Conclusion: We have shown that TOP and infant mortality rates were 35.1 and 28.9%, respectively in pregnancies with fetal malformations. Detailed multidisciplinary counseling must be provided for parents in pregnancies with major congenital abnormalities. K E Y W O R D Scongenital abnormality, pregnancy, termination of pregnancy

Prenatal Diagnosis of Structural Anomaly Among Singletons and Twins

“…In this study, the central nervous system was the most common type of structural anomalies among both singleton and twin pregnancies. In a previous study, the most common fetal malformations were cardiovascular system malformations, central nervous system malformations and diaphragmatic hernias in singletons 16 . Another study found that the main cause of termination of pregnancy in twin pregnancies was fetal central nervous system malformation 6 .…”

“…In a previous study, the most common fetal malformations were cardiovascular system malformations, central nervous system malformations and diaphragmatic hernias in singletons. 16 Another study found that the main cause of termination of pregnancy in twin pregnancies was fetal central nervous system malformation. 6 Glinianaia et al 7 also found that twins had higher rates of all major types of congenital anomalies than singletons, including central nervous/musculoskeletal/genitourinary system malformations.…”

Retrospective clinical evaluation of indications for termination of pregnancies due to fetal anomaly

“…Early diagnosis of congenital abnormalities is also important for offering parents all choices, including TOP, both for ethical and legal reasons ( 8 , 9 ). Therefore, TOP is a critical decision that should be taken through a multidisciplinary committee with the parents involvement ( 10 , 11 ).…”

“…In addition, fetal anomalies diagnosed in advanced weeks due to delaying of prenatal diagnosis at earlier gestational weeks may survive despite their anomalies due to improvements in newborn care support units and facilities. However, severe anomalies mostly lead to recurrent interventions and increased morbidity and mortality ( 10 , 20 ).…”