5‐<scp>ALA</scp>‐mediated photodynamic therapy reduces the parasite load in mice infected with <i>Leishmania braziliensis</i>

Souza, Danila Malheiros; Alves, Polyanna Miranda; Silva, M. L. F.; Paulino, Tony de Paiva; Coraspe, H. O.; Mendonça, MM; Ribeiro, Betânia Maria; Silva, M. V. da; Júnior, Virmondes Rodrigues; Rodrigues, Denise Bertulucci Rocha

doi:10.1111/pim.12403

Cited by 20 publications

(10 citation statements)

References 31 publications

(39 reference statements)

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“…As previously seen, ALA-PDT may act through an immune modulation mechanism when applied directly to the lesion (34). This hypothesis was supported by some results that demonstrated a decrease in the parasitic load following an increase in interferon-gamma (INF-g) levels after ALA-PDT of infected mouse paws (36). The increase in INF-g levels is described as causing resistance to infection by L. (L.) major due to the development of protective immunity (37).…”

Section: Ala-pdtsupporting

confidence: 63%

Progress in the photodynamic therapy treatment of Leishmaniasis

Vital-Fujii

Baptista

2021

Braz J Med Biol Res

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Leishmaniasis is a serious and endemic infectious disease that has been reported in more than 90 countries and territories. The classical treatment presents a series of problems ranging from difficulty in administration, development of resistance, and a series of side effects. Photodynamic therapy (PDT) has already shown great potential for use as a treatment for leishmaniasis that is effective and non-invasive, with very minor side effects. PDT can also be inexpensive and easy to administer. In this review, we will report the most recent developments in the field, starting with the chemical diversity of photosensitizers, highlighting important mechanistic aspects, and noting information that may assist in designing and developing new and promising photosensitizer molecules.

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Section: Ala-pdtsupporting

confidence: 63%

Progress in the photodynamic therapy treatment of Leishmaniasis

Vital-Fujii

Baptista

2021

Braz J Med Biol Res

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“…Whereas the dyes such as RB and TB were observed to have inhibitory efficiency against various microbial biofilms formation (Li, Yuan, Jia, Qin, & Wang, 2020;Parasuraman et al, 2019). The porphyrin photosensitizer ALA has been studied to have an inhibitory effect against papillomaviruses, leishmaniasis, and onychomycosis (Souza et al, 2017;Xie et al, 2019). Hence, the overall studies suggest that PDT is an emerging therapy that could be applied in the treatment of wide range of diseases.…”

mentioning

confidence: 99%

Photodynamic sensitizers modulate cytoskeleton structural dynamics in neuronal cells

Dubey

Chinnathambi

2021

Cytoskeleton

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The neuronal cytoskeleton plays a crucial role in maintaining cell integrity and functioning of neurons. Cytoskeleton deformities have been reported to be associated with neurodegenerative diseases thus; cytoskeleton can be targeted for therapeutic strategies. The therapeutic application of photosensitive molecule is termed as photodynamic therapy (PDT). PDT has been applied in the field of dermatology, cancer biology, and antimicrobial therapy. PDT induces several changes in cells, which include induction of apoptosis, DNA damage, and induction of inflammatory response. PDT has been also reported to modulate cytoskeleton such as actin dynamics. The in vitro studies suggested that PDT using dyes such as Toluidine Blue and Rose Bengal effectively modulated the actin cytoskeleton, neurite outgrowth, tubulin, and Tau aggregation. In this review, we focused on the effect of photosensitized molecules on various cytoskeleton proteins. We hypothesize that PDT could have potency against Alzheimer's disease and other neurodegenerative disorders.

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“…Furthermore, since the authors did not find significant differences in the expression levels of different cytokines in PDT treated versus nontreated parasites, they concluded that PDT-mediated killing of the parasite was primarily indirect. Contrary to this, Souza et al report an increase in IFN-g in response to ALA-PDT against L. braziliensis and conclude that the reduction in parasite load was through both direct and indirect mechanisms [461]. However, much work needs to be done before we can generalize the mechanism of action of PDT against Leishmania which may vary among different species.…”

Section: Photodynamic Treatment Of Pathogens: Antimicrobial Pdtmentioning

confidence: 85%

Photodynamic therapy, priming and optical imaging: Potential co-conspirators in treatment design and optimization — a Thomas Dougherty Award for Excellence in PDT paper

Silva

Saad

Thomsen

et al. 2020

J. Porphyrins Phthalocyanines

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Photodynamic therapy is a photochemistry-based approach, approved for the treatment of several malignant and non-malignant pathologies. It relies on the use of a non-toxic, light activatable chemical, photosensitizer, which preferentially accumulates in tissues/cells and, upon irradiation with the appropriate wavelength of light, confers cytotoxicity by generation of reactive molecular species. The preferential accumulation however is not universal and, depending on the anatomical site, the ratio of tumor to normal tissue may be reversed in favor of normal tissue. Under such circumstances, control of the volume of light illumination provides a second handle of selectivity. Singlet oxygen is the putative favorite reactive molecular species although other entities such as nitric oxide have been credibly implicated. Typically, most photosensitizers in current clinical use have a finite quantum yield of fluorescence which is exploited for surgery guidance and can also be incorporated for monitoring and treatment design. In addition, the photodynamic process alters the cellular, stromal, and/or vascular microenvironment transiently in a process termed photodynamic priming, making it more receptive to subsequent additional therapies including chemo- and immunotherapy. Thus, photodynamic priming may be considered as an enabling technology for the more commonly used frontline treatments. Recently, there has been an increase in the exploitation of the theranostic potential of photodynamic therapy in different preclinical and clinical settings with the use of new photosensitizer formulations and combinatorial therapeutic options. The emergence of nanomedicine has further added to the repertoire of photodynamic therapy’s potential and the convergence and co-evolution of these two exciting tools is expected to push the barriers of smart therapies, where such optical approaches might have a special niche. This review provides a perspective on current status of photodynamic therapy in anti-cancer and anti-microbial therapies and it suggests how evolving technologies combined with photochemically-initiated molecular processes may be exploited to become co-conspirators in optimization of treatment outcomes. We also project, at least for the short term, the direction that this modality may be taking in the near future.

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5‐ALA‐mediated photodynamic therapy reduces the parasite load in mice infected with Leishmania braziliensis

Cited by 20 publications

References 31 publications

Progress in the photodynamic therapy treatment of Leishmaniasis

Progress in the photodynamic therapy treatment of Leishmaniasis

Photodynamic sensitizers modulate cytoskeleton structural dynamics in neuronal cells

Photodynamic therapy, priming and optical imaging: Potential co-conspirators in treatment design and optimization — a Thomas Dougherty Award for Excellence in PDT paper

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