5 Population Similarities in the Onset and Rate of Adult Endosteal Bone Loss

Garn, Stanley M.; Rohmann, Christabel G.; Wagner, Betty; Dávila, Gail H.; Ascoli, Werner

doi:10.1097/00003086-196907000-00006

Cited by 43 publications

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“…These findings agree with the observations of others that bone turnover is more pro- Significantly different from osteoporotic periosteal resting, prolonged surface, P < 0.05 nounced on the endosteal surface than on the periosteal surface [16][17][18]. There was more (although not significantly) periosteal bone forming surface in osteoporotics than in controls.…”

Section: Discussionsupporting

confidence: 91%

Scanning electron microscopy of castrate rat bone

Wink

1982

Calcif Tissue Int

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The study describes the SEM appearances of endosteal and periosteal surfaces of anorganic femoral diaphyses from 16-month-old normal and castrate male rats. Different types of surfaces could be recognized in both groups. Percentage areas occupied by each surface type were analyzed with a Ladd Data Analyzing Digitizer. Endosteal surfaces were composed of significantly more (P less than 0.05) incompletely mineralized, forming surface and significantly less (P less than 0.05) completely mineralized, resting surface in castrates than in controls. Both endosteal and periosteal surfaces from experimental bone demonstrated significantly more (P less than 0.05) osteoblast lucunae than did control surfaces, and vascular canal entrances were significantly wider (P less than 0.001) on castrate endosteal surfaces than on control endosteal surfaces. There was a greater proportion of small nodule forming surface/large nodule forming surface in castrate endosteal bone than in control, and a greater proportion prolonged resting surface/fibrous resting surface in control periosteal bone than in castrate. The results indicate that, when viewed in the SEM, anorganic endosteal and periosteal bone surfaces from femoral diaphyses of old castrate male rats demonstrate appearances characteristic of changes in bone turnover that occur with osteoporosis.

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Section: Discussionsupporting

confidence: 91%

Scanning electron microscopy of castrate rat bone

Wink

1982

Calcif Tissue Int

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“…Measurements made from this band outward did not show a loss of cortical width even though there was a marked loss of cortical mass. Also, we did not correct our measurements for possible subperiosteal bone apposition which occurs in humans concomitant with endosteal surface resorption and age-related bone loss [21].…”

Section: Discussionmentioning

confidence: 99%

“…The reasons for this are unclear, although it is known that the rate of bone turnover is higher in cancellous and tubular bones than in compact bones, such as the skull and mandible [22]. Epidemiological surveys have demonstrated an increase in bone resorption, beginning about the third decade and resulting in a loss of skeletal mass, especially in the vertebrae and along endosteal surfaces of tubular bones [21,23]. Also, the age of onset and amount of bone loss differed from bone to bone; the tibia began to lose bone earlier, but lost less than the second metacarpal.…”

Section: Discussionmentioning

confidence: 99%

Effects of castration on the bone structure of male rats: A model of osteoporosis

1980

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Forty young (23-day-old) and thirty old (1-year-old) male rats were castrated and sacrificed with controls at intervals up to 18 months of age. No differences were observed between femurs or mandibles of rats castrated at 23 days and those of controls. Year-old castrate rats developed femoral osteoporosis after 2 months, which became more pronounced 4 months after castration. This was characterized by reductions in femoral density, dry weight, dry weight per unit length, and ash weight, and by the appearance of resorption cavities in diaphyseal walls and a sparsity of trabeculae in metaphyses and epiphyses of castrate femurs. These results indicate that the year-old castrate male rat may be a valuable experimental model for studies of the treatment of osteoporosis.

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“…Estimation of the degree of skeletal mineralization, depending on an individual's living conditions, diet and a type of body build, is a relatively new research aspect also in physical anthropology (Garn et al, 1967(Garn et al, , 1969Smith 1967;Newton-John & Morgan, 1970;Martin et al, 1980Martin et al, , 1985Borkan et al, 1982;Stini, 1990aStini, ,b, 1994Nelson et al, 1991;Prado et al, 1992;Stini et al, 1992;Crews, 1993Crews, , 1997.…”

Section: Introductionmentioning

confidence: 99%

Do environmental disturbances of an individual's growth and development influence the later bone involution processes? A study of two mediaeval populations

Rewekant¹

2001

Intl J of Osteoarchaeology

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Age-dependent cortical bone loss was studied in two mediaeval Polish populations differing with regard to socio-economic status, as well as the intensity of the occurrence of skeletal indicators of living conditions in the early stages of ontogenesis (compression of the skull base and the narrowing of the lumbar vertebral canal). Cortical bone loss was analysed on the basis of the radiographs of the second metacarpal. Cedynia population (better living conditions) is characterized by higher arithmetic means for the height of the skull base in comparison with Słaboszewo group (low socio-economic status). In the case of the vertebral canal index, significant interpopulation differences apply only to men. Similar patterns of difference between groups under study regarding bone loss was also found. It turned out that males from Cedynia had more bone mass in adultus and maturus age categories; in females, these differences concern only adultus category. The study involved an analysis of a relationship between the characteristics measuring reactions to environmental stress in early stages of growth and the intensity of bone loss in adult life. We believe that the results presented justify a conclusion that both phenomena may be interrelated to a considerable degree.

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5 Population Similarities in the Onset and Rate of Adult Endosteal Bone Loss

Cited by 43 publications

References 0 publications

Scanning electron microscopy of castrate rat bone

Scanning electron microscopy of castrate rat bone

Effects of castration on the bone structure of male rats: A model of osteoporosis

Do environmental disturbances of an individual's growth and development influence the later bone involution processes? A study of two mediaeval populations

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