5-Nitroimidazole derivatives as possible antibacterial and antifungal agents

Microwave-Assisted, Solvent-Free and Parallel Synthesis of Some Novel Substituted Imidazoles of Biological Interest

“…On the basis of above facts (as depicted in the introduction) that the novel series of synthesized derivative of aryl imidazoles containing indole moiety may yield compounds with high therapeutic potential. All the synthesized compounds were analyzed by TLC, mp, FT-IR, 1 H-NMR, 13 C-NMR, MASS and elemental analysis. Microwave irradiation was done using microwave oven supplied by catalyst microwave synthesis system, model: CATA-2R.…”

“…A survey of the pertinent literature reveals that aryl imidazoles have been found to possess a wide spectrum of biological activity such as antibacterial, 1) antirheumatoid arthritis, 2) antitubercular, 3) antiviral, 4) antiepileptic, 5) anti-inflammatory 6) and anticancer activities. [7][8][9] Since, we have made an attempt to synthesize and screen aryl imidazoles which are incorporated with some antibacterial pharmacophores such as sulphanilamide, its bioisoester PABA (p-aminobenzoic acid), INH (isoniazid) and p-amino phenol by using both microwave assisted synthesis as well as conventional synthetic method and screened them as potential antibacterial, anticancer, anthelmintic and antitubercular agents.…”

Synthesis, characterization, and antimicrobial evaluation of some new hydrazinecarbothioamide, 1,2,4-triazole and 1,3,4-thiadiazole derivatives

“…In view of these facts and as a continuation of our research on the biological properties of 1,2,4-triazoleand 1,3,4-thiadiazole containing derivatives [12][13][14][15][16][17][18] , we have designed and synthesized a number of imidazo [2,1-b] thiazole substituted fused 1,2,4-triazole and 1,3,4-thiadiazole systems, as potential antibacterial and antifungal agents.…”

Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines

“…Among five membered heterocycles, pyrazoline and imidazole are represents great importance in biological activities like, antidepressant [18], anticonvulsant [19], antimicrobial [20], analgesics [21] and antitumor [22]. In fact, pyrazoline derivative is now widely used in the market as antiinflammatory [23], analgesics [24], antibacterial [25], antifungal [26], antituberculosis [27], anticonvolusant [28] and potential anticytokine agents [29,30]. Recently, some attention has also been focused upon the reactions of hydroxyl substituted chalcones can be O-alkylated under the basic medium with a suitable alkylating agent to give bifunctional bis-chalcones molecules which are formed by liking two chalcone moieties together through the carbon chains of varying length and structures.…”