Synthesis and in-vitro antibacterial activity of some alkoxy based N-substituted-5-(furan-2-yl)-phenyl-bis-pyrazolines

Synthesis and in-vitro antibacterial activity of some bis-5-(thiophen-2-yl)-carbothioamide-pyrazoline derivatives

“…Furthermore, the goal of this work is to synthesize a series of new bis-pyrazolines containing two systematically pyrazoline ring for the study of their structure-activity relationships and evaluated their antibacterial activity against strain of Aeromonas hydrophila, Yersinia enterocolitica, Listeria monocytogenes and Staphylococcus aureus, responsible for intestinal diseases. In our recent studies, the ongoing research in our laboratory showed that bis-pyrazoline derivatives 2a and 2e are good candidate for these studies [16]. As part of our continuous efforts in this area, a series of some new bis- [3-(2-oxy-phenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide]-pyrazoline derivatives have been synthesized according to Scheme 1 and evaluated for their antibacterial activities by using disk diffusion method.…”

“…The bis-pyrazoline ring is also an important building block in medicinal chemistry and has led to the discovery of a number of derivatives endowed with anti-inflammatory, antitubercular, antitumour and antidiabetic [11][12][13][14][15][16] significances of bis-pyrazolines [17,18]. Furthermore, the goal of this work is to synthesize a series of new bis-pyrazolines containing two systematically pyrazoline ring for the study of their structure-activity relationships and evaluated their antibacterial activity against strain of Aeromonas hydrophila, Yersinia enterocolitica, Listeria monocytogenes and Staphylococcus aureus, responsible for intestinal diseases.…”

Probing the spectral response of a new class of bioactive pyrazoline derivative in homogeneous solvents and cyclodextrin nanocavities: a spectroscopic exploration appended by quantum chemical calculations and molecular docking analysis

“…In recent years, pyrazoline compounds have gained intense attention from medicinal chemists and clinicians because of their extensive biological activities as antifungal, antiviral, antitubercular and insecticidal agents. [1][2][3][4] However the poor solubility of pyrazoline compounds 2 in the aqueous media limits their applications in medicinal as well as pharmaceutical fields. One of the key solutions of this problem is the use of cyclodextrins as carriers.…”

“…In this report, 5-(19-(4bromophenyl)-3a9,49,59,69,6a9-hexahydrocyclopentapyrazoline)-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile (PZ) is selected as a guest molecule to form an inclusion complex with CD for the improvement of its water solubility which is necessary for its use in the medicinal and pharmaceutical industries. This new class of pyrazole-substituted 29-pyrazolines with an inbuilt bromo substituent may be used as potential bromo-organics in pharmaceuticals, intermediates for agrochemicals and industrially valuable new materials 1,9 such as semiconductor molecular crystals. Moreover, pyrazoline compounds are pH-sensitive and their suitability for use in biological systems is well known.…”