5-Hydroxytryptamine (Serotonin): Biphasic Dose Responses

Calabrese, Edward J.

doi:10.1080/20014091111820

Cited by 23 publications

(14 citation statements)

References 15 publications

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“…In fact, the case is just the opposite. As early as 2001, a series of articles was published on a range of endogenous agonists: prostaglandins, nitric oxide, estrogens and related compounds, androgens, adrenergic agonists, adenosine, serotonin, dopamine and opiates that display hormetic biphasic dose‐response. These articles documented that the mechanisms of biphasic dose‐response were clearly established to the level of receptor and, in a number of cases, to further levels of molecular detail.…”

Section: Hormesis Historical Backgroundmentioning

confidence: 99%

Biphasic effects of THC in memory and cognition

Calabrese

Rubio‐Casillas

2018

Eur J Clin Investigation

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A generally undesired effect of cannabis smoking is a reversible disruption of short-term memory induced by delta-9-tetrahydrocannabinol (THC), the primary psychoactive component of cannabis. However, this paradigm has been recently challenged by a group of scientists who have shown that THC is also able to improve neurological function in old animals when chronically administered at low concentrations. Moreover, recent studies demonstrated that THC paradoxically promotes hippocampal neurogenesis, prevents neurodegenerative processes occurring in animal models of Alzheimer's disease, protects from inflammationinduced cognitive damage and restores memory and cognitive function in old mice. With the aim to reconcile these seemingly contradictory facts, this work will show that such paradox can be explained within the framework of hormesis, defined as a biphasic dose-response.

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Section: Hormesis Historical Backgroundmentioning

confidence: 99%

Biphasic effects of THC in memory and cognition

Calabrese

Rubio‐Casillas

2018

Eur J Clin Investigation

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“…This type of scheme has been demonstrated repeatedly in various receptor families. It is believed to be very generalizable, and it has been applied to numerous biological agents/systems, such as prostaglandins [99], estrogens [100], androgens [101], adrenergics [102], adenosine [103], 5‐hydroxytryptamine [104], dopamine [105], opiates [106], amyloid β‐peptide [107], peptides [108], apoptosis [109], and cell migration/chemotaxia [110].…”

Section: Has Hormesis Ever Been Mechanistically Explained?mentioning

confidence: 99%

Hormesis: Why it is important to toxicology and toxicologists

Calabrese

2008

Enviro Toxic and Chemistry

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621

233

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Abstract-This article provides a comprehensive review of hormesis, a dose-response concept that is characterized by a low-dose stimulation and a high-dose inhibition. The article traces the historical foundations of hormesis, its quantitative features and mechanistic foundations, and its risk assessment implications. The article indicates that the hormetic dose response is the most fundamental dose response, significantly outcompeting other leading dose-response models in large-scale, head-to-head evaluations. The hormetic dose response is highly generalizable, being independent of biological model, endpoint measured, chemical class, and interindividual variability. Hormesis also provides a framework for the study and assessment of chemical mixtures, incorporating the concept of additivity and synergism. Because the hormetic biphasic dose response represents a general pattern of biological responsiveness, it is expected that it will become progressively more significant within toxicological evaluation and risk assessment practices as well as have numerous biomedical applications.

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“…This type of scheme has been demonstrated repeatedly in various receptor families. It is believed to be very generalizable, and it has been applied to numerous biological agents/systems, such as prostaglandins [99], estrogens [100], androgens [101], adrenergics [102], adenosine [103], 5-hydroxytryptamine [104], dopamine [105], opiates [106], amyloid ␤-peptide [107], peptides [108], apoptosis [109], and cell migration/chemotaxia [110].…”

Section: Has Hormesis Ever Been Mechanistically Explained?mentioning

confidence: 99%

Hormesis: Why it is Important to Toxicology and Toxicologists

Calabrese¹

2007

Environ Toxicol Chem

211

215

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This article provides a comprehensive review of hormesis, a dose-response concept that is characterized by a low-dose stimulation and a high-dose inhibition. The article traces the historical foundations of hormesis, its quantitative features and mechanistic foundations, and its risk assessment implications. The article indicates that the hormetic dose response is the most fundamental dose response, significantly outcompeting other leading dose-response models in large-scale, head-to-head evaluations. The hormetic dose response is highly generalizable, being independent of biological model, endpoint measured, chemical class, and interindividual variability. Hormesis also provides a framework for the study and assessment of chemical mixtures, incorporating the concept of additivity and synergism. Because the hormetic biphasic dose response represents a general pattern of biological responsiveness, it is expected that it will become progressively more significant within toxicological evaluation and risk assessment practices as well as have numerous biomedical applications.

show abstract

5-Hydroxytryptamine (Serotonin): Biphasic Dose Responses

Cited by 23 publications

References 15 publications

Biphasic effects of THC in memory and cognition

Biphasic effects of THC in memory and cognition

Hormesis: Why it is important to toxicology and toxicologists

Hormesis: Why it is Important to Toxicology and Toxicologists

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