5-HT1A-Receptor Subtype Mediates the Effect of Fluvoxamine, a Selective Serotonin Reuptake Inhibitor, on Marble-Burying Behavior in Mice

Ichimaru, Yasuyuki; Egawa, Takashi; Sawa, Aiko

doi:10.1254/jjp.68.65

Cited by 147 publications

(123 citation statements)

References 12 publications

(9 reference statements)

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“…The similarity in effect seen between inactivation and blockade is in line with previous studies evaluating models of depression [7,13,35]. In both the forced swim test and the tail suspension test an antidepressant-like effect has been observed after inactivation of the 5-HT 7 receptor [7,13] and also after treatment with a selective antagonist [13,35].It has previously been found that agonism at the 5-HT 1A receptor also reduces marble burying behavior [19,23]. This is of interest in relation to previously described relationships between 5-HT 1A and 5-HT 7 receptors.…”

supporting

confidence: 87%

“…Establishing good animal models for OCD has proved to be exceedingly difficult, most clearly demonstrated by the large number of models tried [21,23]. Marble burying is one of the more well-established models for OCD [19,27,28]. New models of supposedly stereotypic behavior, such as the screen chewing and head dipping tests used along with marble burying in the present study, are also continuously being developed and tested [2].…”

mentioning

confidence: 95%

“…Studies have also suggested that 5-HT 2A receptor agonism might have beneficial anti-OCD effects [25,29]. Other evidence suggest an involvement of the 5-HT 1A receptor, since agonists at this receptor, specifically, 8-hydroxy-2 (di-n-propylamino)tetralin (8-OH-DPAT) have been shown to reduce OCD-like behavior [19,23].As 8-OH-DPAT is also an agonist at 5-HT 7 receptors, and since 5-HT 7 receptors influence behaviors modified by antidepressants, it is of interest to study the possible involvement of this receptor in models of OCD. We have investigated the effects of inactivation or blockade of the 5-HT 7 receptor on marble burying, screen chewing, and head dipping behavior.…”

mentioning

confidence: 99%

“…The generation of the 5-HT 7 −/− mouse strain has been described previously [10]. The mice used in this study had been back-crossed on a C57BL/6J background for at least 16 generations.Marble-burying behavior was studied as previously described [19,36]. Twenty-four glass marbles (1.5 cm in diameter) were placed on 5 cm of sawdust bedding along the perimeter of a clear plastic box (44 × 22 × 20 cm).…”

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confidence: 99%

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The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder

Hedlund

Sutcliffe

2007

Neuroscience Letters

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The 5-HT 7 receptor has been suggested as a new putative target for the treatment of neuropsychiatric disorders, especially depression. This hypothesis is based on the finding that antidepressant drugs have relatively high affinity for the 5-HT 7 receptor, and that inactivation or blockade of the receptor leads to an antidepressant-like profile in behavioral models and sleep parameters. Obsessivecompulsive disorder is also believed to involve the serotonergic system and is treated using antidepressants, thus it is of interest to study the possible role of the 5-HT 7 receptor in this disorder. We have evaluated the effect of inactivation or pharmacological blockade of the 5-HT 7 receptor in three mouse behavioral models that are believed to mimic some of the stereotypic aspects of obsessive-compulsive disorder. In the most well established behavioral model, marble burying, both inactivation and blockade of the 5-HT 7 receptor reduced stereotypic behavior in that the number of marbles buried decreased. In two newer, less well characterized models, head dipping and plasticmesh screen chewing, there was no difference between wild-type mice and mice lacking the 5-HT 7 receptor. Taken together the data confirms and expands on previous findings that the 5-HT 7 receptor is of importance for behaviors affected by antidepressants, and suggests that the 5-HT 7 receptor might be of relevance as a target for the treatment of obsessive-compulsive disorder. Keywordsserotonin; marble burying; head dipping; screen chewing; SB-269970The 5-HT 7 receptor, one of the most recently discovered receptors for serotonin [12], has been found to modulate behaviors affected by antidepressant drugs. In both the forced swim test and the tail suspension test, inactivation or blockade of the 5-HT 7 receptor lead to antidepressantlike behavior [7,13,35]. Furthermore, inactivation or pharmacological blockade of the 5-HT 7 receptor lead to changes in rapid eye movement sleep that are opposite to those seen in depression [8,13]. In addition, it has been shown that certain antidepressants might exert some of their effects by acting directly at the 5-HT 7 receptor [26].Obsessive-compulsive disorder (OCD) is a debilitating disease with an overall prevalence of close to 1 % [15]. There is strong evidence in support of a significant role for 5-HT in OCD and antidepressant drugs, mainly selective serotonin reuptake inhibitors (SSRIs), are the pharmacological treatment of choice for OCD [4,15]. However, as many as 40 % of patients do not respond to currently available treatment options [15], so continued research is necessary. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the c...

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supporting

confidence: 87%

mentioning

confidence: 95%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder

Hedlund

Sutcliffe

2007

Neuroscience Letters

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“…Inhibition of object burying was originally suggested as a screening test for anxiolytic activity, but several studies in the last ten years led to the conclusion that marble-burying behavior does not model anxiety, but may rather be related to compulsive behaviors (Albelda and Joel, 2012). The predictability of the marbleburying test after acute drugs administration has been widely demonstrated in research articles (Gawali et al, 2016;Ichimaru et al, 1995;Joel, 2006;Kalariya et al, 2015). Thus, we decided to compare acute effects of atomoxetine on the marble-burying test with its chronic effects on patients with a primary diagnosis of hoarding disorder.…”

Section: Pre-clinical Investigationmentioning

confidence: 99%

Atomoxetine for hoarding disorder: A pre-clinical and clinical investigation

Grassi

Micheli

Mannelli

et al. 2016

Journal of Psychiatric Research

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Effect of Hypericum perforatum on marble‐burying by mice

Skalisz

Beijamini

Andreatini

2004

Phytotherapy Research

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The effect of Hypericum perforatum extract (LI 160) at a dose that exerts an antidepressive-like effect was studied in mice in the marble-burying test. Acute Hypericum perforatum (150, 300 and 500 mg/kg, p.o.) reduced immobility time in the forced swimming test. The number of marbles buried, but not locomotor activity, was reduced by acute treatment with Hypericum perforatum (150 and 300 mg/kg, p.o.). However, this effect was not seen after chronic treatment (21 days) with Hypericum perforatum (300 mg/kg, p.o.). Thus, Hypericum perforatum extract, at antidepressant dose, exerts an acute anxiolytic drug effect on the marble-burying test, which could indicate a potential anti-obsessive effect, although the development of tolerance could be an important drawback.

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5-HT1A-Receptor Subtype Mediates the Effect of Fluvoxamine, a Selective Serotonin Reuptake Inhibitor, on Marble-Burying Behavior in Mice

Cited by 147 publications

References 12 publications

The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder

The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder

Atomoxetine for hoarding disorder: A pre-clinical and clinical investigation

Effect of Hypericum perforatum on marble‐burying by mice

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