Effect of <i>Hypericum perforatum</i> on marble‐burying by mice

Skalisz, Luana L; Beijamini, Vanessa; Andreatini, Roberto

doi:10.1002/ptr.1450

Cited by 14 publications

(10 citation statements)

References 30 publications

(24 reference statements)

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“…In accordance with our results, the suppressive effect of St John's wort (300 mg kg À1 , p.o.) on marble-burying behaviour in mice was reported by Skalisz et al (2004). We have previously found that brain serotonin transporter occupancy by SSRIs significantly correlated well with their suppressive effects on marble-burying behaviour after oral administration in mice (unpublished observation), suggesting that St John's wort exerts its suppressive effect on marble-burying behaviour through the activation of serotonergic neurotransmission.…”

Section: Discussionsupporting

confidence: 53%

Effects of oral administration of extracts of Hypericum perforatum (St John's wort) on brain serotonin transporter, serotonin uptake and behaviour in mice

Hirano

Kato

Uchida

et al. 2004

Journal of Pharmacy and Pharmacology

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The pharmacological effects of extracts of Hypericum perforatum (St John's wort) were characterized in-vitro and ex-vivo, in relation to its behavioural effects. In in-vitro experiments, St John's wort inhibited brain synaptosomal [(3)H]serotonin uptake in mice with little effect on specific [(3)H]paroxetine binding. For selective serotonin-reuptake inhibitors (SSRIs), the IC50 value for [(3)H]serotonin uptake (molar concentration of unlabelled drug necessary to displace 50% of specific uptake) correlated well with the inhibition constant K(i) value for [(3)H]paroxetine binding in mouse brain. Oral administration of St John's wort (900 mg kg(-1)), paroxetine (1 mg kg(-1)) and sertraline (10 mg kg(-1)) brought about significant increases in the K(m) value for [(3)H]serotonin uptake into brain synaptosomes 4 h later, and only SSRIs suppressed specific [(3)H]paroxetine binding in mouse brain. St John's wort and SSRIs significantly inhibited marble-burying behaviour in mice and the time-course of attenuation of this behaviour by St John's wort was similar to that of [(3)H]serotonin uptake inhibition. In the forced swimming test, St John's wort, but not SSRIs, suppressed the immobility time of mice after oral administration. These results provide the first in-vivo evidence to suggest that the mode of antidepressant action of St John's wort differs from that of SSRIs. Thus, this study may have a significant impact on phytotherapy with St John's wort.

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Section: Discussionsupporting

confidence: 53%

Effects of oral administration of extracts of Hypericum perforatum (St John's wort) on brain serotonin transporter, serotonin uptake and behaviour in mice

Hirano

Kato

Uchida

et al. 2004

Journal of Pharmacy and Pharmacology

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“…No food or water was present. 30 min later, animals were removed, and the number of marbles at least two-third buried in the sawdust was recorded [26,27]. …”

Section: Methodsmentioning

confidence: 99%

Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: Involvement of antioxidant and anti-apoptotic mechanisms

Ding

Zhang

Masood

et al. 2014

Behavioural Brain Research

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Stress occurs in everyday life, but the relationship between stress and the onset or development of depression/anxiety remains unknown. Increasing evidence suggests that the impairment of antioxidant defense and the neuronal cell death are important in the process of emotional disorders. Chronic stress impairs the homeostasis of antioxidants/oxidation, which results in the aberrant stimulation of the cell cycle proteins where cGMP-PKG signaling is thought to have an inhibitory role. Phosphodiesterase 2 (PDE2) is linked to cGMP-PKG signaling and highly expressed in the limbic brain regions including hippocampus and amygdala, which may play important roles in the treatment of depression and anxiety. To address the possible effects of PDE2 inhibitors on depression-/anxiety-like behaviors and the underlying mechanisms, Bay 60-7550 (0.75, 1.5 and 3 mg/kg, i.p.) was administered 30 min before chronic stress. The results suggested that Bay 60-7550 not only restored the behavioral changes but also regulated Cu/Zn superoxide dismutase (SOD) levels differentially in hippocampus and amygdala, which were increased in the hippocampus while decreased in the amygdala. It was also significant that Bay 60-7550 regulated the abnormalities of pro- and anti-apoptotic components, such as Bax, Caspase 3 and Bcl-2, and the indicator of PKG signaling characterized by pVASPser239, in these two brain regions. The results suggested that Bay 60-7550 is able to alleviate oxidative stress and mediate part of the apoptotic machinery in neuronal cells possibly through SOD-cGMP/PKG-anti-apoptosis signaling and that inhibition of PDE2 may represent a novel therapeutic target for psychiatric disorders, such as depression and anxiety.

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“…No food or water was present. The number of marbles that were at least two-thirds buried after 30 min was recorded (Skalisz et al, 2004;Dekeyne et al, 2008).…”

Section: Marble-burying Testmentioning

confidence: 99%

Anxiolytic-like effects of acute and chronic treatment with Achillea millefolium L. extract

Baretta

Felizardo

Bimbato

et al. 2012

Journal of Ethnopharmacology

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Effect of Hypericum perforatum on marble‐burying by mice

Cited by 14 publications

References 30 publications

Effects of oral administration of extracts of Hypericum perforatum (St John's wort) on brain serotonin transporter, serotonin uptake and behaviour in mice

Effects of oral administration of extracts of Hypericum perforatum (St John's wort) on brain serotonin transporter, serotonin uptake and behaviour in mice

Protective effects of phosphodiesterase 2 inhibitor on depression- and anxiety-like behaviors: Involvement of antioxidant and anti-apoptotic mechanisms

Anxiolytic-like effects of acute and chronic treatment with Achillea millefolium L. extract

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