5-HT1A dysfunction in borderline personality disorder

Hansenne, Michel; Pitchot, William; Pinto, Emmanuel; Reggers, Jean; Scantamburlo, Gabrielle; Fuchs, Sonia; Pirard, Sandrine; Ansseau, Marc

doi:10.1017/s0033291702005445

Cited by 37 publications

(20 citation statements)

References 26 publications

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“…The lack of fit of model (a), which postulates that adult attachment patterns have no effect on BPD, or on impulsivity and aggressiveness, suggests that adult attachment is involved to some degree in the regulation of the system that interrelates BPD, impulsivity, and aggressiveness. Further, in line with previous studies (Dougherty et al, 1999;Hansenne et al, 2002;Links et al, 1999), our best fitting model showed that impulsivity and aggressiveness significantly predict BPD features. Interestingly, this finding was not a spurious effect of the covariation between BPD and ASPD that was observed in this study.…”

Section: Discussionsupporting

confidence: 90%

“…Among basic aspects of personality, impulsivity and aggressiveness have been hypothesized recently to represent core features of BPD (Dougherty, Bjork, Huckabee, Moeller, & Swann, 1999;Hansenne et al, 2002;Links et al, 1999). Although these personality features are influenced to some degree by biological and genetic factors (Moeller, Barratt, Dougherty, Schmitz, & Swann, 2001), the relevance of attachment characteristics is supported by findings that insecurely attached children (Main & Goldwin, 1984), and particularly infants classified as disorganized/disoriented in the Strange Situation (Lyons-Ruth, Repacholi, McLeod, & Silva, 1991), are significantly more likely to manifest highly aggressive behaviors than those with secure attachment.…”

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confidence: 99%

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Modeling the Relationships between Adult Attachment Patterns and Borderline Personality Disorder: The Role of Impulsivity and Aggressiveness

Fossati¹,

Feeney²,

Carretta³

et al. 2005

Journal of Social and Clinical Psychology

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To obtain a better understanding of the associations among Borderline Personality Disorder (BPD), adult attachment patterns, impulsivity, and aggressiveness, we tested four competing models of these relationships: a) BPD is associated with the personality traits of impulsivity and aggressiveness, but adult attachment patterns predict neither BPD nor impulsive/aggressive features; b) adult attachment patterns are significant predictors of BPD but not of impulsive/aggressive traits, although these traits correlate with BPD; c) adult attachment patterns are significant predictors of impulsive and aggressive traits, which in turn predict BPD; and d) adult attachment patterns significantly predict both BPD and impulsive/aggressive traits. We assessed 466 consecutively admitted outpatients using the Structured Clinical Interview for DSM-IV Axis II Personality Disorders (V. 2.0), the Attachment Style Questionnaire, the Barratt Impulsiveness Scale-11, and the Aggression Questionnaire. Maximum likelihood structural equation modeling of the covariance matrix showed that model (c) was the best fitting model (χ 2 (21) = 31.67, p > .05, RMSEA = .023, test of close fit p > .85). This result indicates that adult attachment patterns act indirectly as risk factors for BPD because of their relationships with aggressive/impulsive personality traits.

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Modeling the Relationships between Adult Attachment Patterns and Borderline Personality Disorder: The Role of Impulsivity and Aggressiveness

Fossati¹,

Feeney²,

Carretta³

et al. 2005

Journal of Social and Clinical Psychology

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“…Using multimodal PET/fMRI, we previously reported that the density of 5-HT 1A autoreceptors accounts for 30-44% of variability in amygdala reactivity in healthy adults (Fisher et al 2006), confirming the important role of 5-HT 1A autoreceptors in modulating the activity of serotonergic target regions. Given the critical role of 5-HT 1A autoreceptors in regulating 5-HT signaling and its resulting influence on the functioning of major brain targets, such as the amygdala, as well as complex behavioral processes (Cowen et al 1994;Hansenne et al 2002;Lesch and Gutknecht 2004), it is important to identify sources of emergent variability in 5-HT 1A function.…”

Section: Trait Anxiety the Amygdala And Serotoninmentioning

confidence: 99%

Toward a Mechanistic Understanding of How Variability in Neurobiology Shapes Individual Differences in Behavior

Bogdan

Carré

Hariri

2011

Current Topics in Behavioral Neurosciences

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Research has begun to identify how variability in brain function contributes to individual differences in complex behavioral traits. Examining variability in molecular signaling pathways with emerging and established methodologies such as pharmacologic fMRI, multimodal PET/fMRI, and hormonal assays are beginning to provide a mechanistic understanding of how individual differences in brain function arise. Against this background, functional genetic polymorphisms are being utilized to understand the origins of variability in signaling pathways as well as to efficiently model how such emergent variability impacts behaviorally relevant brain function and health outcomes. This chapter provides an overview of a research strategy that integrates these complimentary levels of analysis; existing empirical data is used to illustrate the effectiveness of this approach in illuminating the mechanistic neurobiology of individual differences in complex behavioral traits. This chapter also discusses how such efforts can contribute to the identification of predictive risk markers that interact with unique environmental factors to precipitate psychopathology.

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“…A recent study on BPD inpatients [Hansenne et al, 2002] showed a blunted prolactin (PRL) response to flesinoxan (a more specific 5-HT agent than fenfluramine) challenge, even after controlling for MDD comorbidity. Notably, these responses were still lower in BPD inpatients with a history of suicide attempts.…”

Section: Impulsivitymentioning

confidence: 99%

Personality traits as intermediary phenotypes in suicidal behavior: Genetic issues

Baud

2005

American J of Med Genetics Pt C

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A genetic contribution to the risk of suicidal behavior is now supported by many studies. It probably involves specific factors acting on their own, independently of the genetic transmission of associated psychiatric disorders. A history of childhood maltreatment, adverse events, psychosocial stress, psychological traits and major psychiatric disorders all appear to contribute to the global risk of suicide attempt or completion. The interplay between previously identified risk factors, different as they are in nature and degree of complexity, still remains to be clarified. A stress-diathesis model has been proposed, where trait-like genetic and developmental risk factors (the diathesis) interact through still unknown mechanisms with actual (stress-related) factors to create the conditions for a suicidal gesture. Disentangling the effects of these risk factors, and specifically the effects of the genetic factors influencing these different pathological conditions, appears to be a difficult task. Indeed the results of candidate gene association studies suggest that genetic vulnerability factors for various related psychiatric phenotypes (major psychiatric disorders and personality traits) partly overlap with more specific factors predisposing to suicidal behavior. Personality traits are partly under genetic control and may be closer to the genetic effects than psychiatric syndromes. We review here the available data on the genetics of personality traits presumably involved in suicidal behavior, focusing on the association studies carried out with serotonin-related genes. We suggest that future studies on the genetic vulnerability to suicidal behavior should include the investigation of endophenotypes, with the aim of deciphering the mechanisms underlying the genetic susceptibility to these closely associated phenotypes.

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5-HT1A dysfunction in borderline personality disorder

Cited by 37 publications

References 26 publications

Modeling the Relationships between Adult Attachment Patterns and Borderline Personality Disorder: The Role of Impulsivity and Aggressiveness

Modeling the Relationships between Adult Attachment Patterns and Borderline Personality Disorder: The Role of Impulsivity and Aggressiveness

Toward a Mechanistic Understanding of How Variability in Neurobiology Shapes Individual Differences in Behavior

Personality traits as intermediary phenotypes in suicidal behavior: Genetic issues

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