5-HT Mediation of Alcohol Self-Administration, Tolerance and Dependence: Pre-Clinical Studies

Higgins, Guy A.; Le, Anh D.; Sellers, Edward M.

doi:10.1007/978-3-642-78435-4_7

Cited by 4 publications

(3 citation statements)

References 129 publications

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“…Data has shown that ethanol withdrawal alters the function of 5-HT in the brain, suggesting that reduced 5-HT activity in the brain may be a secondary consequence of ethanol withdrawal. 5-HT, however, does not appear to play a role in the development of dependence on ethanol (11,32). …”

Section: Discussionmentioning

confidence: 91%

“…Such receptors include serotonin (5-HT) (11,35) voltage gated calcium channels (17); receptors for the excitatory amino acid, glutamate (12,35); GABA neurotransmission (23,44); catecholamines such as norepinephrine and dopamine (39). Changes in each of these receptors are suspected in not only producing dependence on alcohol, but also in claiming responsibility for the withdrawal syndrome.…”

Section: Discussionmentioning

confidence: 99%

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Alcohol usage and abrupt cessation modulate diurnal activity

Norrell

Reyes-Vasquez

Burau

et al. 2010

Brain Research Bulletin

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Alcohol has many effects throughout the body. The effect on circadian rhythms and the correlation of these effects to withdrawal effects of alcohol present interesting findings. By measuring 3 planes of activity of female Sprague-Dawley rats during alcohol usage and continuing study through the first two days following withdrawal of alcohol allow for the observation of a drastic modulation of the circadian pattern of activity.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Alcohol usage and abrupt cessation modulate diurnal activity

Norrell

Reyes-Vasquez

Burau

et al. 2010

Brain Research Bulletin

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“…By using a relatively young sample (i.e., SRE-5 and parental monitoring were measured during the teenage years) and including only SRE items that pertain to the first five drinking occasions, we were able to capture a purer subjective response that was less likely to be confounded by acquired tolerance ( Corbin et al, 2013 ; Morean & Corbin, 2008 ). We made this choice because there is evidence that acquired tolerance and early level of response (i.e., innate tolerance) are distinct ( Higgins, Le, & Sellers, 1995 ; Morean & Corbin, 2008 ). Yet, one study found that participants with high tolerance were 2.8 times more likely to have the SS relative to the LL genotype ( Turker et al, 1998 ), pointing to the possibility that acquired tolerance and early level of response are related.…”

Section: Discussionmentioning

confidence: 99%

Effects of the serotonin transporter gene, sensitivity of response to alcohol, and parental monitoring on risk for problem alcohol use

Cope

Munier

Trucco

et al. 2017

Alcohol

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The serotonin transporter-linked polymorphic region (5-HTTLPR) of the serotonin transporter gene (SLC6A4) has been previously associated with alcohol-related risk. Most findings point to short (S) allele carriers being at increased risk for negative alcohol outcomes relative to long allele homozygotes, although some work indicates a more complex relationship. The current prospective study aimed to clarify how and under what circumstances variations in 5-HTTLPR transmit risk for various alcohol-related outcomes. Participants were 218 adolescents and young adults (29% female) enrolled in the Michigan Longitudinal Study. We tested a moderated mediation model with 5-HTTLPR as the predictor, Self-Rating of the Effects of Alcohol (SRE) score as the mediator, alcohol-related outcomes as the dependent variables, parental monitoring as the moderator of the SRE to alcohol outcomes path, and prior drinks, sex, age, and body mass index as covariates. Four alcohol-related outcomes were tested. The S allele was associated with higher SRE scores (i.e., lower response to alcohol). Parental monitoring was a significant moderator: At low levels of parental monitoring, higher SRE scores predicted more drinks consumed and binge drinking episodes. At high levels of monitoring, higher SRE scores were significantly related to fewer alcohol-related problems. Findings suggest that one mechanism by which 5-HTTLPR variation transmits alcohol-related risk is through level of response to alcohol. Furthermore, the strength and direction of this effect varied by level of parental monitoring, indicating that even in the presence of genetic and physiological vulnerability, parents can influence the likelihood of offspring developing problematic alcohol-related behaviors.

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