5‑Fluorouracil loaded chitosan/polyacrylic acid/Fe3O4 magnetic nanocomposite hydrogel as a potential anticancer drug delivery system

Amini‐Fazl, Mohammad Sadegh; Mohammadi, Réza; Kheiri, Karim

doi:10.1016/j.ijbiomac.2019.04.005

Cited by 111 publications

(32 citation statements)

References 62 publications

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“…Enteric-coated nanoparticles are one of the drug delivery technologies that can improve the bioavailability of drugs by oral administration, 50,[133][134][135] increase intracellular penetration and retention time, control the release of encapsulated drugs and targeted delivery in specific parts of the gastrointestinal tract such as in the treatment of colorectal cancer. 136 Cellular uptake and efficacy of nanoparticle drug delivery systems for colorectal cancer therapy are influenced by several factors, namely, size, shape, and surface chemistry. [137][138][139] The size of the drug delivery carrier plays an important role in colorectal cancer therapy.…”

Section: Enteric-coated Nanoparticle Formulations For Colorectal Cancermentioning

confidence: 99%

<p>Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System</p>

Wathoni

Nguyen

Rusdin

et al. 2020

DDDT

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Colorectal cancer is one of the most common cancer diseases with the increase of cases prevalence >5% every year. Multidrug resistance mechanisms and non-localized therapy become primary problems of chemotherapy drugs for curing colorectal cancer disease. Therefore, the enteric-coated nanoparticle system has been studied and proved to be able to resolve those problems with good performance for colorectal cancer. The highlight of our review aims to summarize and discuss the enteric-coated nanoparticle drug delivery system specific for colorectal cancer disease. The main and supporting literatures were collected from published research articles of journals indexed in Scopus and PubMed databases. In the oral route of administration, Eudragit pH-sensitive copolymer as a coating agent prevents the degradation of the nanoparticle system from the gastric fluid and releases drug to intestinal-colon track. Therefore, it provides a colon-specific targeting ability. Impressively, enteric-coated nanoparticles having a sustained release profile significantly increase the cytotoxic effect of chemotherapeutic drugs and achieve cell-specific target delivery. The enteric-coated nanoparticle drug delivery system represents an excellent modification to improve the effectiveness and performance of anticancer drugs for colorectal cancer disease in terms of the oral route of administration.

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Section: Enteric-coated Nanoparticle Formulations For Colorectal Cancermentioning

confidence: 99%

<p>Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System</p>

Wathoni

Nguyen

Rusdin

et al. 2020

DDDT

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“…Recently, Chitosan (CS) and polyacrylic acid (PAA) coated 94 nm iron oxide magnetic nanoparticles showed promising potentiality as a drug carrier module to deliver anticancer drug 5‐ fluorouracil. [ 137 ] The drug loading capacity of CS/PAA/Fe 3 O 4 was reported as 100%; however, these nanocarrier suffers from initial burst release of 40% of the loaded drugs which can introduce challenges in certain applications where sustained release is paramount. [ 138 ] To surmount initial burst release challenge, Hyati et al.…”

Section: Biomedical Applications Of Mnpsmentioning

confidence: 99%

Recent progress of magnetic nanoparticles in biomedical applications: A review

et al. 2021

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Magnetic nanoparticles (MNPs) offer tremendous potentialities in biomedical applications for a long while. Since these materials' interactions in biological media largely rely on their crystal structures, sizes, and shapes, detailed studies on their synthesis mechanism for medicinal aspects are crucial. Despite many review reports that have already been published on MNPs, they mainly have focused either on their perspective in biomedical applications or their synthesis and characterization along with functionalization mechanisms as individual entities. For this reason, this review uncovers a comprehensive insight into the ongoing improvement of fabrication processes, surface functionalization of MNPs for biomedical applications together. Besides, various magnetic nanocomposite (MNCs) for smart drug delivery, recent hyperthermia treatment, lab‐on‐a‐chip, and magnetic bio‐separation, and some of the recent emerging imaging techniques using MNPs are discussed. A detailed analysis of toxicity, challenges, and recent progress of clinical trials of MNPs is sketched out to open numerous entryways for advanced research on MNPs for biomedical applications.

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“…Various kinds of cells and molecules can be encapsulated homogeneously into the magnetic hydrogels and then targeted to the pathological sites with minimal invasiveness (Wu et al, 2018;Chen X. et al, 2019b;Shi et al, 2019;Wu H. et al, 2019;Xu et al, 2019). Several polymers, including ionic-response polymers (e.g., sodium alginate), natural biocompatible polymers (e.g., chitosan), and synthetic polymers (e.g., polyacrylic acid), conjugated with the magnetic particles have been used to fabricate the injectable hydrogels for therapeutic applications (Jalili et al, 2017;Hu et al, 2018;Amini-Fazl et al, 2019). These magnetic hydrogels could be guided to the diseased sites via external magnetic fields and exert a drug release influence there.…”

Section: Injectable Magnetic Hydrogel's Application In Tissue Engineementioning

confidence: 99%

Recent Advances on Magnetic Sensitive Hydrogels in Tissue Engineering

et al. 2020

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Tissue engineering is a promising strategy for the repair and regeneration of damaged tissues or organs. Biomaterials are one of the most important components in tissue engineering. Recently, magnetic hydrogels, which are fabricated using iron oxide-based particles and different types of hydrogel matrices, are becoming more and more attractive in biomedical applications by taking advantage of their biocompatibility, controlled architectures, and smart response to magnetic field remotely. In this literature review, the aim is to summarize the current development of magnetically sensitive smart hydrogels in tissue engineering, which is of great importance but has not yet been comprehensively viewed.

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5‑Fluorouracil loaded chitosan/polyacrylic acid/Fe3O4 magnetic nanocomposite hydrogel as a potential anticancer drug delivery system

Cited by 111 publications

References 62 publications

<p>Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System</p>

<p>Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System</p>

Recent progress of magnetic nanoparticles in biomedical applications: A review

Recent Advances on Magnetic Sensitive Hydrogels in Tissue Engineering

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