5-Fluorouracil and curcumin co-encapsulated chitosan/reduced graphene oxide nanocomposites against human colon cancer cell lines

Dhanavel, S.; Revathy, T.A.; Sivaranjani, T.; Sivakumar, K.; Palani, P.; Narayanan, Vijaykrishnan; Stephen, A.

doi:10.1007/s00289-019-02734-x

Cited by 64 publications

(31 citation statements)

References 44 publications

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“…Chitosan has also been used to deliver and release the chemotherapy drug 5-Fluorouracil (5-Fu) to targeted carcinoma cells both in vitro and in vivo [17]. In one study, 5-Fu was electrospun with chitosan and polycaprolactone to analyse drug release [18].…”

Section: Introductionmentioning

confidence: 99%

Electrospun Fibres of Chitosan/PVP for the Effective Chemotherapeutic Drug Delivery of 5-Fluorouracil

et al. 2021

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Electrospun nanofibrous mats consisting of chitosan (CS) and polyvinylpyrrolidone (PVP) were constructed. Tuning of solution and process parameters was performed and resulted in an electrospun system containing a 6:4 ratio of PVP:CS. This is a significant increase in the proportion of spun CS on the previously reported highest ratio PVP:CS blend. SEM analysis showed that the nanofibrous mats with 4 wt% CS/6 wt% PVP (sample E) comprised homogenous, uniform fibres with an average diameter of 0.569 μm. XPS analysis showed that the surface of the samples consisted of PVP. Raman and FTIR analysis revealed intermolecular interactions (via H-bonding) between PVP and CS. In FTIR spectra, the contribution of chitosan to CS/PVP complexes was shown by the downshift of the C=O band and by the linear increase in intensity of C-O stretching in CS. XPS analysis showed a smaller shift at the binding energy 531 eV, which relates to the amide of the acetylated functional groups. The obtained results demonstrate a sensitivity of Raman and FTIR tests to the presence of chitosan in PVP:CS blend. The chemotherapy drug 5-Fu was incorporated into the constructs and cell viability studies were performed. WST-8 viability assay showed that exposure of A549 human alveolar basal epithelial cells to 10 mg/mL 5-Fu loaded fibres was most effective at killing cells over 24 h. On the other hand, the constructs with loading of 1 mg/mL of drug were not efficient at killing A549 human alveolar basal epithelial cells. This study showed that CS/PVP/5-Fu constructs have potential in chemotherapeutic drug delivery systems.

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Section: Introductionmentioning

confidence: 99%

Electrospun Fibres of Chitosan/PVP for the Effective Chemotherapeutic Drug Delivery of 5-Fluorouracil

et al. 2021

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“…5-FU and CUR loaded CS/rGO nanocomposite showing drug EE >90% exhibited synergistic cytotoxicity and effectively inhibited the growth of HT-29 colon cancer cells with IC 50 of 23.8 μg/mL [ 235 ]. 5-FU and CUR-loaded nanocomposites consisting of Pd nanospheres on CS/rGO exhibited sustained release of the drugs and inhibited the growth of human colon cancer cells (HT-29) [ 236 ].…”

Section: Graphene Oxidementioning

confidence: 99%

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Jampílek

Kráľová

2021

Materials

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Carbon is one of the most abundant elements on Earth. In addition to the well-known crystallographic modifications such as graphite and diamond, other allotropic carbon modifications such as graphene-based nanomaterials and carbon nanotubes have recently come to the fore. These carbon nanomaterials can be designed to help deliver or target drugs more efficiently and to innovate therapeutic approaches, especially for cancer treatment, but also for the development of new diagnostic agents for malignancies and are expected to help combine molecular imaging for diagnosis with therapies. This paper summarizes the latest designed drug delivery nanosystems based on graphene, graphene quantum dots, graphene oxide, reduced graphene oxide and carbon nanotubes, mainly for anticancer therapy.

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“…To address this problem, Hashemi et al introduced a rGO-based nanocarrier with high paclitaxel loading capacity through functionalization and stabilization with R9 peptides, where pristine rGO sheets were found to be unstable in aqueous solutions and aggregated to decrease the surface area available for drug loading [ 71 ]. In a different study, Dhanavel et al developed dual drug-encapsulated chitosan/rGO nanocomposite by entrapping 5-fluorouracil (5-FU) and curcumin in chitosan/sodium tripolyphosphate gel in the presence of rGO nanosheet for dual drug delivery to HT-29 colon cancer cells [ 72 ]. The synergistic cytotoxicity was observed for dual drug-loaded nanocomposite to inhibit the growth of HT-29 colon cancer cells compared with single drug therapy.…”

Section: Application Of Reduced Graphene Oxide (Rgo) In Cancer Thementioning

confidence: 99%

Functionalized Reduced Graphene Oxide as a Versatile Tool for Cancer Therapy

Dash

Jose

et al. 2021

IJMS

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Cancer is one of the deadliest diseases in human history with extremely poor prognosis. Although many traditional therapeutic modalities—such as surgery, chemotherapy, and radiation therapy—have proved to be successful in inhibiting the growth of tumor cells, their side effects may vastly limited the actual benefits and patient acceptance. In this context, a nanomedicine approach for cancer therapy using functionalized nanomaterial has been gaining ground recently. Considering the ability to carry various anticancer drugs and to act as a photothermal agent, the use of carbon-based nanomaterials for cancer therapy has advanced rapidly. Within those nanomaterials, reduced graphene oxide (rGO), a graphene family 2D carbon nanomaterial, emerged as a good candidate for cancer photothermal therapy due to its excellent photothermal conversion in the near infrared range, large specific surface area for drug loading, as well as functional groups for functionalization with molecules such as photosensitizers, siRNA, ligands, etc. By unique design, multifunctional nanosystems could be designed based on rGO, which are endowed with promising temperature/pH-dependent drug/gene delivery abilities for multimodal cancer therapy. This could be further augmented by additional advantages offered by functionalized rGO, such as high biocompatibility, targeted delivery, and enhanced photothermal effects. Herewith, we first provide an overview of the most effective reducing agents for rGO synthesis via chemical reduction. This was followed by in-depth review of application of functionalized rGO in different cancer treatment modalities such as chemotherapy, photothermal therapy and/or photodynamic therapy, gene therapy, chemotherapy/phototherapy, and photothermal/immunotherapy.

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5-Fluorouracil and curcumin co-encapsulated chitosan/reduced graphene oxide nanocomposites against human colon cancer cell lines

Cited by 64 publications

References 44 publications

Electrospun Fibres of Chitosan/PVP for the Effective Chemotherapeutic Drug Delivery of 5-Fluorouracil

Electrospun Fibres of Chitosan/PVP for the Effective Chemotherapeutic Drug Delivery of 5-Fluorouracil

Advances in Drug Delivery Nanosystems Using Graphene-Based Materials and Carbon Nanotubes

Functionalized Reduced Graphene Oxide as a Versatile Tool for Cancer Therapy

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