Abstract:Interferon exerts antiviral and various non-antiviral activities on cells. For the development of the antiviral state in cells against exogenous infection of cytolytic viruses such as vesicular stomatitis virus and encephalomyocarditis virus (EMCV), induction of 2'-5'-oligo(A) synthetase or double-stranded (ds)-RNA-dependent protein kinase, or both, has been shown to have a crucial role (Revel 1979). However, in some cases, the antiviral effects of interferon are virus-specific (Nilsen
et al.
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