5% Amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers

Khandwala, Atul; Inwegen, R. G. Van; Charney, Martha R.; Alfano, Michael C.

doi:10.1016/s1079-2104(97)90010-x

Cited by 40 publications

(20 citation statements)

References 3 publications

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“…All subject selection, recruitment, and experimental procedures were approved by the Khandwala et al 44 report outcomes for a large vehicle-controlled, randomized, double-blind, parallel group, multicenter clinical study involving 1335 subjects who used amlexanox oral paste (Aphthasol ® , prescription required) to treat their aphthous ulcers. It is noted those treated with this product had complete resolution of pain within three to five days in one study location and three to eight days in another.…”

Section: Methodsmentioning

confidence: 99%

Review of Over-the-counter Treatments for Aphthous Ulceration and Results from Use of a Dissolving Oral Patch Containing Glycyrrhiza Complex Herbal Extract

Burgess

Ven²,

Martin

et al. 2008

The Journal of Contemporary Dental Practice

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Aim:The aim of this article is to present a review of over-the-counter (OTC) treatment strategies used for aphthous ulcerations and to provide results from the use of an herbal extract containing glycyrrhiza.Background: Aphthous ulceration, a disease of the intra-oral mucosa, is a common condition of unknown etiology that is often self-managed by OTC (no prescription required) medication.Review: Preparations currently on the market can be divided into several categories: local anesthetic agents, oxygenating agents, mouth rinses, and barriers -further subdivided into paste coverings such as gels or dissolvable or non-dissolvable adhesive patches containing plant extract or synthetic drugs. Other strategies include herbs, hematinic replacement, or off-label OTC drug applications. While many OTC treatments are available and accepted for use with aphthous ulceration, a review of the literature via a number of published research search engines suggests that to date there are no randomized controlled studies to demonstrate OTC preparations do more than manage symptoms. Exceptions include OTC cyanoacrylate products and CankerMelts ® GX patches which include glycyrrhiza (licorice) extract. The use of CankerMelts has been shown to alter the course of the condition by reducing lesion duration, size, and pain. Abstract © Seer PublishingSummary: The results of the studies reviewed here suggest CankerMelts GX discs may be as effective as amlexanox (which must be prescribed) in reducing pain and speeding healing. In addition it can be applied by the patient without the adverse events associated with cyanoacrylate formulations.

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Section: Methodsmentioning

confidence: 99%

Review of Over-the-counter Treatments for Aphthous Ulceration and Results from Use of a Dissolving Oral Patch Containing Glycyrrhiza Complex Herbal Extract

Burgess

Ven²,

Martin

et al. 2008

The Journal of Contemporary Dental Practice

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“…One RCT of 335 patients with RAS in the US reported that 5% amlexanox significantly reduced the pain and time of healing. Other open studies have also suggested that amlexanox may result in some improvement in the signs and symptoms (Greer et al , 1993; Binnie et al , 1997; Khandwala et al , 1997).…”

Section: Other Topical Anti‐inflammatory Agentsmentioning

confidence: 97%

“…Amlexanox has been suggested to be of some benefit in the treatment of RAS. Amlexanox has anti‐allergic and anti‐inflammatory activities, but its exact mode of action in the treatment of RAS remains unknown (Khandwala et al , 1997). One RCT of 335 patients with RAS in the US reported that 5% amlexanox significantly reduced the pain and time of healing.…”

Section: Other Topical Anti‐inflammatory Agentsmentioning

confidence: 99%

Number VI Recurrent aphthous stomatitis

et al. 2005

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Recurrent aphthous stomatitis (RAS; aphthae; canker sores) is a common condition which is characterized by multiple recurrent small, round or ovoid ulcers with circumscribed margins, erythematous haloes, and yellow or grey floors typically presenting first in childhood or adolescence. RAS occurs worldwide although it appears most common in the developed world. The aetiology of RAS is not entirely clear. Despite many studies trying to identify a causal microorganism, RAS does not appear to be infectious. A genetic predisposition is present, as shown by strong associations with genotypes of IL-1beta; IL-6 in RAS patients, and a positive family history in about one-third of patients with RAS. Haematinic deficiency is found in up to 20% of patients. Cessation of smoking may precipitate or exacerbate RAS in some cases. Ulcers similar to RAS may be seen in human immunodeficiency virus disease and some other immune defects, and drugs, especially non-steroidal anti-inflammatory drugs and nicorandil may produce lesions clinically similar to RAS. Topical corticosteroids can often control RAS. However, the treatment of RAS remains unsatisfactory, as most therapies only reduce the severity of the ulceration and do not stop recurrence.

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“…Amlexanox The antiallergic agent amlexanox 5% (amoxanox) may significantly reduce ulcer pain and time to healing (166–169).…”

mentioning

confidence: 99%

Aphthous ulcerations

2002

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Recurrent aphthous stomatitis (RAS) is a chronic condition, usually with a childhood or adolescent onset and with a tendency to diminish in frequency and severity with age. Most patients are otherwise healthy. The differential diagnosis for “aphthae” includes vesiculobullous diseases, granulomas, and even squamous cell carcinomas. The onset of aphthous‐like lesions in adults suggests the possibility of developing a more complex systemic disorder such as Behcet's syndrome or inflammatory bowel disease. Treatment includes correction of underlying diseases or predisposing causes, and the use of topical and systemic anti‐inflammatory agents or immunomodulating drugs.

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5% Amlexanox oral paste, a new treatment for recurrent minor aphthous ulcers

Cited by 40 publications

References 3 publications

Review of Over-the-counter Treatments for Aphthous Ulceration and Results from Use of a Dissolving Oral Patch Containing Glycyrrhiza Complex Herbal Extract

Review of Over-the-counter Treatments for Aphthous Ulceration and Results from Use of a Dissolving Oral Patch Containing Glycyrrhiza Complex Herbal Extract

Number VI Recurrent aphthous stomatitis

Aphthous ulcerations

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