5-aminolevulinic acid-induced fluorescence endoscopy applied at secondary transurethral resection after conventional resection of primary superficial bladder tumors

Filbeck, Thomas; Roessler, Wolfgang; Knuechel, Ruth; Straub, Michael; Kiel, H.; Wieland, W.F.

doi:10.1016/s0090-4295(98)00430-0

Cited by 77 publications

(43 citation statements)

References 6 publications

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“…52 False positive results were associated with previous TURBT, intravesical therapy, or nonspecific inflammation. 53 Recently a phase III multicentre study by Grossman and colleagues compared fluorescence and white light cystoscopy. Fluorescence cystoscopy detected at least 1 more Ta and T1 papillary tumour than the white light cystoscopy in approximately a third of the patients with such tumours.…”

Section: Fluorescence Cystoscopymentioning

confidence: 99%

Update on the management of non-muscle invasive bladder cancer

Aldousari

Kassouf

2013

CUAJ

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Non-muscle invasive bladder cancer (NMIBC) is a heterogeneous population of tumours accounting for 80% of bladder cancers. Over the years, the management of this disease has been changing with improvements in results and outcomes. In this review, we focus on the latest updates on the management of NMIBC.Can Urol Assoc J 2010;4(1):56-64 RésuméLe cancer de la vessie sans envahissement musculaire est un groupe hétérogène de tumeurs représentant 80 % des cancers de la vessie. Au fil des années, la prise en charge de cette maladie a évolué, et les résultats et issues thérapeutiques se sont améliorés. Dans l'article qui suit, nous présentons les plus récents développe-ments dans la prise en charge de ce type de cancer.

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Section: Fluorescence Cystoscopymentioning

confidence: 99%

Update on the management of non-muscle invasive bladder cancer

Aldousari

Kassouf

2013

CUAJ

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“…Areas of dysplasia, CIS and papillary tumors fluoresce and become visible. The sensitivity of this technique was reported to be as high as 96% [15]; however, specificity was low (34%) in the study reported by Filbeck et al [16]. The technique therefore tended to overdiagnose abnormalities and if used in routine practice would result in unnecessary TUR and overtreatment of some patients.…”

Section: Transurethral Resectionmentioning

confidence: 99%

Treatment of Superficial Bladder Tumors: Achievements and Needs

Bouffioux²,

et al. 2000

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“…PpIX fluorescence is observed even in cases of radiation necrosis without tumor recurrence or a metastatic brain tumor's edema field (Utsuki et al, 2007a). For whatever reason, PpIX fluorescence is observed even outside the brain in cases of strong inflammatory cell infiltration (Filbeck et al;1999). A gadolinium-enhancing effect on MRI often occurs in regions of inflammatory cell infiltration.…”

Section: Psudopositive Fluorescencementioning

confidence: 99%

Intraoperative Photodynamic Diagnosis of Brain Tumors Using 5-Aminolevulinic Acid

Utsuki¹,

Oka²,

Fujii³

2011

Diagnostic Techniques and Surgical Management of Brain Tumors

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Diagnostic Techniques and Surgical Management of Brain Tumors 228 2. 5-ALA metabolic pathway 2.1 5-ALA metabolism in normal cells 5-ALA is a substance that naturally exists in the body. In the first stage, 5-Ala is produced via the condensation of glycine and succinyl-CoA by ALA synthetase (ALAS) in the mitochondria. This process receives negative feedback from heme, which is the endproduct. 5-ALA is actively transported via cytoplasm. In the next step, porphobilinogen (PBG) is created from ALA via ALA dehydratase. The actions of PBG deaminase (PBGD) and uroporphyrinogen III synthase compress 4 PBG molecules, effectively cyclizing a tetrapyrrole chain and producing uroporphyrinogen III. Uroporphyrinogen III is converted by uroporphyrinogen decarboxylase into coproporphyrinogen III, which is exposed to coproporphyrinogen oxidase in the mitochondrial intermembrane space. Decarboxylation and oxidation of the propionic side chains of the vinyl groups' rings A and B ultimately form protoporphyrinogen IX in the cell nucleus. PpIX is synthesized from protoporphyrinogen IX via protoporphyrinogen oxidase activity, and heme is synthesized via the uptake of iron into the tetrapyrrole structure by ferrochelatase in the mitochondrial membrane ( Fig.

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5-aminolevulinic acid-induced fluorescence endoscopy applied at secondary transurethral resection after conventional resection of primary superficial bladder tumors

Cited by 77 publications

References 6 publications

Update on the management of non-muscle invasive bladder cancer

Update on the management of non-muscle invasive bladder cancer

Treatment of Superficial Bladder Tumors: Achievements and Needs

Intraoperative Photodynamic Diagnosis of Brain Tumors Using 5-Aminolevulinic Acid

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