5,8-Dihydroxy-3,6,7-trimethoxyflavone from Gnaphalium gaudichaudianum

The Genus Gnaphalium L. (Compositae): Phytochemical and Pharmacological Characteristics

“…To date, 28 flavone derivatives, 1 – 28 , 37 flavonol derivatives, 29 – 65 , one flavanone, 66 , and two chalcone derivatives, 67 , 68 , have been reported, which constitute the majority of the secondary metabolites from the genus Gnaphalium [17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48]. Among them, 28 compounds, 2 – 5 , 7 – 10 , 13 – 16 , 23 , 27 , 28 , 32 – 39 , 41 , 43 – 45 , and 68 , were isolated as O -glycosides.…”

Structure–Activity Relationship and Prediction of the Electron‐Transfer Potential of the Xanthones Series

“…The hydroquinone moiety, however, is very rare in other phenolic antioxidants. For example, among the thousands of documented flavonoids, there are only a few flavonoids with a hydroquinone moiety, and they include rhodionin, 5,8‐dihydroxy‐3,6,7‐trimethoxyflavone, 5,8‐dihydroxy‐6,7‐dimethoxyflavone, 5,8‐dihydroxy‐6,7,4′‐trimethoxyflavone, 5,8‐dihydroxy‐6,7,3′,4′,5′‐pentamethoxyflavone, and isothymusin . This hydroquinone moiety is hardly found in other phenolics .…”

Effect of Gnaphalium conoideum HBK on guinea pig airway smooth muscle: role of L-type Ca2+ channels

“…Examples of such chemical components are 4,2 ,4 -trihydroxy-6 -methoxychalcone-4 -glucoside, 5,7-dihydroxy-3,6,8-trimethoxyflavone, 13-epi-cyclosclareol, (−)-16-kauren-19-oic acid, (−)-11␤-acetoxy- 16-kauren-19-oic acid, 13-epi-sclareol, sitosterol, stigmasterol, acetylenic chloroenol ether, 5,8-dihydroxy-3,6,7-trimethoxyflavone, 5,8-dihydroxy-6,7-dimethoxyflavone, gnaphaliin, and calycopterin (Meragelman et al, 2003;Maruyama et al, 1974;Torrenegra et al, 1980Torrenegra et al, , 1992Bohlmann and Ziesche, 1980;Guerreiro et al, 1982). Few studies evaluating the therapeutic potential of this genus have been performed until now.…”