5,7-Dihydroxychromone-2-carboxylic acid and it's transition-metal (Mn and Zn) chelates as non-thiol radioprotective agents

Hosseinimehr, Seyed Jalal; Emami, Saeed; Taghdisi, Seyed Mohammad; Akhlaghpoor, Shahram

doi:10.1016/j.ejmech.2007.04.013

Cited by 11 publications

(4 citation statements)

References 18 publications

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“…Basically this methodology consists in the condensation of the 2-hydroxyacetophenone with diethyl oxalate in the presence of sodium ethoxide in ethanol (EtOH) followed by the oxopropanoate intermediate cyclisation under acidic conditions [236][237][238][239] . Other modifications to the synthesis of chromones via Claisen condensation were also reported [237,240,241] . Essentially, the reported modifications were focused in finding mild reaction conditions, such as the employment of triethylamine as solvent and base [242] although the use of other catalysts like LiH [243] , NaH in THF [195] and NaH in pyridine [204,244,245] have also been described.…”

Section: Intermediate the Second Step The Cyclization Of The Intermmentioning

confidence: 92%

“…It was stated that the use of tert -butylethyl oxalate led to a shorter reaction time and better yields. Other authors have synthetized several chromone derivatives by performing the condensation of different 2-hydroxyphenones with ethyl chlorooxoacetate and in situ cyclization in the presence of pyridine, , without the requirement of the acidification step for ring closure.…”

Section: Methods Of Synthesis Of Simple Chromonesmentioning

confidence: 99%

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Chromone: A Valid Scaffold in Medicinal Chemistry

et al. 2014

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The last few decades have provided stunning progresses in the understanding of physiopathology of several diseases. The remarkable progress in research fields, like genetics, immunology, neurobiology, among others, as well as the advent of more powerful tools, have made it possible to characterize, monitor, and understand far more of the basis of physiology and disease. However, for some diseases the treatment remains a problematic issue as the efforts performed so far were not translated into therapeutic solutions. Notwithstanding the steady increase in the total amount of FCUP

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Section: Intermediate the Second Step The Cyclization Of The Intermmentioning

confidence: 92%

Section: Methods Of Synthesis Of Simple Chromonesmentioning

confidence: 99%

Chromone: A Valid Scaffold in Medicinal Chemistry

et al. 2014

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“…21 Zinc can adopt different geometries with different coordination numbers; they have good pharmacological profiles 22 as anti-radio agents and tumour photosensitizes. [23][24] Zinc complexes have been used for the treatment of Alzheimer disease. 25 In the view of above importance of metal complexes first we have synthesized the metal complexes of Cu(II) and Zn(II) ions and evaluated for their antimicrobial and cytotoxic activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, antimicrobial screening and cytotoxic properties of Cu(II) and Zn(II) complexes with bidentate hydroxylated 1,3-diaryl-2-propene-1-ones ligand

Patil¹,

Zangade

2021

JSCS

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A series of binary metal complexes [halo, hydroxyl and methoxy sub-stituted bis (2-(E) acryloyl)naphthalen-1-yl)oxy)Cu(II) and Zn(II) (C1-C10)] of Cu2+ and Zn2+ ions derived from bi-coordinated hydroxylated 1,3-diaryl-2- -propene-1-ones were synthesized. The newly synthesized metal complexes were structurally determined by FT-IR, 1H NMR, 13CNMR, ESR spectral, XRD and TGA analysis. The FT-IR and ESR studies demonstrated that interactions between metal ions with ligands occur through carbonyl oxygen and deprotonated hydroxyl oxygen and corresponds to square-planar geometry for all complexes. In-vitro the metal complexes were screened and evaluated for their antimicrobial and cytotoxic activity. The complexes C1 and C4 showed the significant antimicrobial activity while the remaining complexes were showed the moderately antimicrobial activity against the tested pathogens. The complexes were evaluated for cytotoxic activity against the organism Artemia salina. The complexes C2, C3, C4 and C5 were showed the LC50 values as 630.45, 969.99, 921.94 and 918.41 ?M mL-1 respectively. Further complexes were evaluated for anticancer activity against liver cancer cell line (Hep G2) in comparison with 5-fluorouracil standard. The complex C5 showed the significant IC50 value 58.94 ?g mL-1. Therefore the present study is useful to develop the new class of antimicrobial and anticancer agents.

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“…7 Moreover, they have good pharmacological profiles 8 as radio-protective agents and tumor photosensitizers. 9,10 Zinc complexes have kindled interest, as they are less toxic than complexes of non-essential metals and have been used as drugs for the treatment of Alzheimer's disease, showing bactericidal, antimicrobial and cytotoxic activity. 11a Nickel(II) complexes of macrocyclic ligands are well known to be biologically important and interesting because of their anticarcinogenic, antibacterial and antifungal properties.…”

Section: Introductionmentioning

confidence: 99%

New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged (endo,endo)-bicyclo [2.2.1]hept-5-ene-2,3-dicarboxylate: Synthesis, characterization, antimicrobial and cytotoxic activity

Nikolić¹,

Dražić²,

Antić-Stanković³

et al. 2019

JSCS

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New carboxylate complexes of the tetraazamacrocyclic ligand N,N',N'',N'''-tetrakis(2-pyridilmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc) with Ni(II) and Zn(II) as central ions were prepared. In mixed-ligand complexes (endo,endo)-bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate dianion (C 9 H 8 O 4 2-) is also coordinated to metal ions. The complexes were characterized by elemental analysis (C, H, N), FTIR and UV-Vis spectroscopy, molar conductivity determination and magnetic susceptibility measurement at room temperature. The analytical data of the complexes show the formation of binuclear [Ni 2 (C 9 H 8 O 4)tpmc](ClO 4) 2 •4H 2 O and tetranuclear [Zn 4 (C 9 H 8 O 4)(tpmc) 2 ](ClO 4) 6 • •CH 3 CN•KClO 4 •4H 2 O complexes. In tetranuclear Zn(II) complex bicyclic dicarboxylate ligand is most likely to be bridge coordinated, and in binuclear Ni(II) complex it is coordinated in a combined bridged manner with chelate rings formation. In both complexes macrocyclic ligand was exo coordinated, out of cyclam ring and adopts a boat conformation. The Zn(II) complex is one of the rare tetranuclear Zn(II)-tpmc complexes with carboxylate ion bridging two Zn 2 tpmc units. The complexes were tested for antibacterial activity against Gram-positive bacteria Staphylococcus aureus (ATCC 25923) and Bacillus subtilis (ATCC 6633), Gram-negative bacterium Escherichia coli (ATCC 25922), and yeast Candida albicans (ATCC 10231), and were screened for antiproliferative activity against human cervix adenocarcinoma (HeLa) and human myelogenous leukemia (K562) cell lines.

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5,7-Dihydroxychromone-2-carboxylic acid and it's transition-metal (Mn and Zn) chelates as non-thiol radioprotective agents

Cited by 11 publications

References 18 publications

Chromone: A Valid Scaffold in Medicinal Chemistry

Chromone: A Valid Scaffold in Medicinal Chemistry

Synthesis, characterization, antimicrobial screening and cytotoxic properties of Cu(II) and Zn(II) complexes with bidentate hydroxylated 1,3-diaryl-2-propene-1-ones ligand

New mixed-ligand Ni(II) and Zn(II) macrocyclic complexes with bridged (endo,endo)-bicyclo [2.2.1]hept-5-ene-2,3-dicarboxylate: Synthesis, characterization, antimicrobial and cytotoxic activity

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