4D prints of flexible dosage forms using thermoplastic polyurethane with hybrid shape memory effect

Großmann, Linus; Kieckhöfer, Maximilian; Krause, Julius

doi:10.1016/j.ejpb.2022.11.009

Cited by 6 publications

(2 citation statements)

References 80 publications

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“…This issue can be solved by designing intelligent polymer chains or deformable devices through 3D printing. [493][494][495][496] This approach helps a drug-loaded stimuliresponsive capsule release the medicine in a controlled manner under a specific stimulus at a specified body location. [497][498][499] Unlike traditional manufacturing methods, 3D printing is highly advantageous to develop personalized, made-on-demand, and unprecedented complex structures, which enhance the effectiveness, accessibility, and safety of drugs.…”

Section: Biomedical Sectormentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

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Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, soft robots, wearable devices, sensors, self‐expanding structures, and biomedical devices, thanks to their ability to change their shapes and functional properties in response to external stimuli including light, humidity, heat, pH, electric field, solvent, and magnetic field or combinations of two or more of these stimuli. In recent years, additive manufacturing (AM) aka three‐dimensional (3D) printing technology of these SRPs, also known as four‐dimensional (4D) printing, has gained phenomenal attention in different engineering fields, thanks to its unique ability to develop complex, personalized, and innovative structures, which undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, and other complex morphological transformations. Herein, an effort has been made to provide insightful information about the AM techniques, type of SRPs, and their applications including, but not limited to tissue engineering, soft robots, bionics, actuators, sensors, construction, and smart textiles. This article also incorporates the current challenges and prospects, hoping to provide an insightful basis for the utilization of this technology in different engineering fields. It is expected that the amalgamation of 3D printing with SRPs would provide unparalleled advantages in different engineering arenas.This article is protected by copyright. All rights reserved.

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Section: Biomedical Sectormentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

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“…Since GRDDS were introduced, various approaches have been followed to achieve gastric retention: expansion or shape changing using different designs with a slim or collapsed configuration that allows swallowing and returns to its original shape in situ [ 10 , 11 , 12 , 13 ], muco-adhesion [ 14 , 15 ], high-density systems that sink to the bottom of the stomach, and floating or low-density systems that have lower density than that of the gastric medium (1.004 g/cm 3 ) and hence float in the stomach [ 16 , 17 , 18 , 19 , 20 ]. These different approaches can be used by themselves or in combination with each other in the design of GRDDS [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics

2023

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Three-dimensional printing (3DP) technology enables an important improvement in the design of new drug delivery systems, such as gastroretentive floating tablets. These systems show a better temporal and spatial control of the drug release and can be customized based on individual therapeutic needs. The aim of this work was to prepare 3DP gastroretentive floating tablets designed to provide a controlled release of the API. Metformin was used as a non-molten model drug and hydroxypropylmethyl cellulose with null or negligible toxicity was the main carrier. High drug loads were assayed. Another objective was to maintain the release kinetics as robust as possible when varying drug doses from one patient to another. Floating tablets using 10–50% w/w drug-loaded filaments were obtained by Fused Deposition Modelling (FDM) 3DP. The sealing layers of our design allowed successful buoyancy of the systems and sustained drug release for more than 8 h. Moreover, the effect of different variables on the drug release behaviour was studied. It should be highlighted that the robustness of the release kinetics was affected by varying the internal mesh size, and therefore the drug load. This could represent a step forward in the personalization of the treatments, a key advantage of 3DP technology in the pharmaceutical field.

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Recent Advancement in 3D and 4D Printing

Sardar,

Mishra,

Pandey

et al. 2024

Lecture Notes in Mechanical Engineering

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4D prints of flexible dosage forms using thermoplastic polyurethane with hybrid shape memory effect

Cited by 6 publications

References 80 publications

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Hydrophilic High Drug-Loaded 3D Printed Gastroretentive System with Robust Release Kinetics

Recent Advancement in 3D and 4D Printing

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