49-OR: Consequences of allocating deceased donor organs based on recipient antibody specificities

Clinical significance of anti-HLA antibodies detected by Luminex®: Enhancing the interpretation of CDC-BXM and important post-transplantation monitoring tools

“…Studies have been conducted to investigate the performance of virtual crossmatch in predicting flow crossmatch outcomes in highly sensitized patients [37,38]. Extensive antibody investigation using sensitive techniques such as Luminex PRA and single-antigen beads allows virtual crossmatch to mimic the sensitivity of the final crossmatch, and also reduces time and cost for organ allocation for deceased donor organs [37,39 -41].…”

“…In contrast, patients undergoing transplantion with a positive flow crossmatch but negative virtual crossmatch had significantly poorer graft survival [38]. A combination of antibody detection assays from different manufacturers or different systems may improve the accuracy of virtual crossmatch.…”