476: Underdiagnosis and Overdiagnosis of Prostate Cancer

Graif, Theresa; Yu, Xiaoying; Loeb, Stacy; Gashti, Sara N.; Griffin, Christopher; Han, Misop; Roehl, Kimberly A.; Suarez, Brian K.; Catàlona, William J.

doi:10.1016/s0022-5347(18)32732-0

Cited by 2 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using the pathology criteria in the RP specimen for over‐diagnosis of pathological stage T2a, Gleason <7, over‐diagnosis in the Tyrol Project was 19.7% for PSA levels of 2–4 ng/mL and 17.6% for PSA levels of 2–10 ng/mL [34]. In another screening study, using the Ohori criteria for unimportant disease [25], <10% of men underwent treatment for over‐diagnosed prostate cancer [36].…”

Section: Discussionmentioning

confidence: 99%

Tyrol Prostate Cancer Demonstration Project: early detection, treatment, outcome, incidence and mortality

et al. 2008

View full text Add to dashboard Cite

model. A piecewise linear change-point Poisson regression model was used to compare mortality rates in Tyrol and the rest of Austria. Standardized mortality ratios were calculated with reference to the mortality rates in [1986][1987][1988][1989][1990]. RESULTSIn all, 86.6% of eligible men have been tested at least once since 1993. Cancer deaths in Tyrol in 2005 were 54% (95% confidence interval [CI] 34-69%) lower than expected compared with 29% (95% CI 22-

show abstract

Section: Discussionmentioning

confidence: 99%

Tyrol Prostate Cancer Demonstration Project: early detection, treatment, outcome, incidence and mortality

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Using the pathology criteria in the prostatectomy specimen for overdiagnosis of pathologic stage T2a, Gleason <7, overdiagnosis in the Tyrol Project was 19.7% in the PSA range of 2 ng/mL to 4 ng/mL and 17.6% in the PSA range of 2 ng/mL to 10 ng/mL. In another screening study, using the Ohori criteria for unimportant disease, 24 fewer than 10% of men underwent treatment for ‘overdiagnosed’ prostate cancer 25 . Although reduction in prostate cancer mortality rates is important, it is also necessary to consider the effects of prostate cancer screening and treatment on patient quality of life.…”

Section: Appendix In the Japanese Urological Association Guidelines Omentioning

confidence: 99%

“…In another screening study, using the Ohori criteria for unimportant disease, 24 fewer than 10% of men underwent treatment for 'overdiagnosed' prostate cancer. 25 Although reduction in prostate cancer mortality rates is important, it is also necessary to consider the effects of prostate cancer screening and treatment on patient quality of life. Potential gains in survival could be more than offset decrements in quality of life that may result from diagnosis and treatment.…”

Section: Comment From Professor Kenneth Lin MDmentioning

confidence: 99%