446 High Definition White Light Endoscopy (Hdwle) Versus High Definition With Chromoendoscopy (Hdce) in the Detection of Dysplasia in Long Standing Ulcerative Colitis: a Randomized Controlled Trial

Mohammed, Noor; Kant, Prashant; Abid, Faisal; Rotimi, Olorunda; Prasad, Padmini; Hamlin, John; Everett, Simon; Rembacken, Björn; Subramanian, Venkat R.

doi:10.1016/j.gie.2015.03.1237

Cited by 32 publications

(42 citation statements)

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“…The CE-incremental detection yield for dysplasia was comparable between standard definition and high definition (51.5% vs 52.3%,p ¼ 0.30) (currently e-pub ahead of print need reference). Furthermore, an interim report of a randomized trial further supports the significant value of high definition chromoendoscopy in IBD surveillance colonoscopy to detect more dysplasia compared to high definition white light colonoscopy [26]. …”

Section: Alternative Techniquesmentioning

confidence: 87%

“…Additionally, chromoendoscopy detected significantly more patients with endoscopically visible dysplasia compared with SD white-light colonoscopy (incremental yield ¼ 7% [95% CI 3.0e10.0]; relative increase ¼ 2.3 [95% CI 1.4e3.7]) [24]. One prospective, study using high definition colonoscopy in 75 patients with IBD identified significantly more dysplasia with chromoendoscopy (21%) vs white-light alone (9%; P ¼ .007) [25] Recently, an interim analysis of a randomized trial also showed significantly higher detection of dysplastic lesions with high definition plus chromoendoscopy compared to high-definition white-light colonoscopy alone: 0.26 vs. 0.12 lesions per patient [26]. Despite adding an average of approximately 11 minutes to the procedure [24], chromoendoscopy has been found to be cost effective [27].…”

Section: Chromoendoscopymentioning

confidence: 99%

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Surveillance of patients with inflammatory bowel disease

East

Kaltenbach

2016

Best Practice & Research Clinical Gastroenterology

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Patients with inflammatory bowel disease involving the colon are at increased risk for developing colorectal cancer. Colonoscopy surveillance is important to identify and treat IBD associated dysplasia. The SCENIC consensus provides evidence-based recommendations for optimal surveillance and management of dysplasia in IBD. Chromoendoscopy, with the surface application of dyes to enhance mucosal visualization, is the superior endoscopic surveillance strategy to detect dysplasia. Most dysplasia is visible, and can be endoscopically resected. Future studies should determine the effect of new surveillance strategies on the incidence of CRC and mortality in patients with IBD.

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Section: Alternative Techniquesmentioning

confidence: 87%

Section: Chromoendoscopymentioning

confidence: 99%

Surveillance of patients with inflammatory bowel disease

East

Kaltenbach

2016

Best Practice & Research Clinical Gastroenterology

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“…The search retrieved 565 citations (Figure ). Twenty‐one trials involving 2889 participants with IBD were eligible for inclusion in the review . We could not extract data from three crossover trials because results at the end of the first phase of the study were not reported.…”

Section: Resultsmentioning

confidence: 99%

“…We could not extract data from three crossover trials because results at the end of the first phase of the study were not reported. Thus, 18 trials involving 2638 participants were included in our analysis . Table S2 shows the study design, interventions and population characteristics in the 21 trials included in the review.…”

Section: Resultsmentioning

confidence: 99%

Systematic review with network meta‐analysis: endoscopic techniques for dysplasia surveillance in inflammatory bowel disease

Iannone

Ruospo²,

Palmer

et al. 2019

Aliment Pharmacol Ther

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Summary Background International guidelines recommend dysplasia surveillance in IBD. Aim To compare endoscopic techniques for dysplasia surveillance Methods We searched MEDLINE, Embase, CENTRAL for randomised trials through May 2019. We estimated odds ratios (ORs) for binary and mean differences (MDs) for continuous outcomes, using frequentist random‐effects network meta‐analysis. We assessed study risk of bias and appraised evidence certainty using GRADE. Results Eighteen trials (2638 participants) were included. Standard definition white‐light endoscopy (OR 0.44, 95% CI 0.26‐0.73; high certainty) and i‐SCAN (OR 0.47, 95% CI 0.25‐0.90; moderate certainty) had lower odds of detecting neoplasia than chromoendoscopy. Fujinon intelligent colour enhancement (FICE), standard definition white‐light endoscopy and i‐SCAN had lower odds for this outcome than full spectrum high definition white‐light endoscopy (ORs 0.02 to 0.15; low certainty). Standard definition white‐light endoscopy had lower odds of detecting nonpolypoid neoplasia than full spectrum high definition white‐light endoscopy, narrow band imaging, chromoendoscopy and high definition white‐light endoscopy (ORs 0.01‐0.14; moderate certainty). Full spectrum high definition white‐light endoscopy ranked as the best technique for both outcomes (moderate certainty). Standard definition white‐light endoscopy had lower odds of detecting neoplasia by target biopsy (OR 0.27, 95% CI 0.08‐0.91) and had shorter procedure time (MD −14.81 minutes, 95% CI −25.03, −4.06) than chromoendoscopy (moderate certainty). Conclusions Chromoendoscopy, high definition white‐light endoscopy, narrow band imaging, autofluorescence, FICE and full spectrum high definition white‐light endoscopy may be comparable for dysplasia surveillance. Standard definition white‐light endoscopy and i‐SCAN probably provide lower yields for neoplasia identification. Full spectrum high definition white‐light endoscopy may represent the first‐line approach.

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“…(9) Thus far, preliminary reports of two small, randomized controlled trials comparing high-definition white light colonoscopy to chromoendoscopy have yielded conflicting results. (10,11)…”

mentioning

confidence: 99%

Editorial: Clarity and Caution in the Natural History of Low-Grade Dysplasia in Ulcerative Colitis

Kisiel

Loftus

2015

American Journal of Gastroenterology

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A substantial body of evidence supports the safety of conservative endoscopic polypectomy for discrete, adenomatous-appearing, colonic polyps in patients with ulcerative colitis. Much less is known about the clinicopathologic factors of low-grade dysplastic lesions at risk for subsequent high-grade dysplasia or colorectal cancer. In this issue of the American Journal of Gastroenterology, Choi and colleagues examine the outcome of patients with low-grade dysplasia participating in a surveillance cohort at St. Mark’s Hospital, one of the oldest and largest programs of its kind. Long-term follow-up of many, well-phenotyped, low-grade dysplasia cases sheds new light, and raises new questions, on our ulcerative colitis surveillance practice.

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446 High Definition White Light Endoscopy (Hdwle) Versus High Definition With Chromoendoscopy (Hdce) in the Detection of Dysplasia in Long Standing Ulcerative Colitis: a Randomized Controlled Trial

Cited by 32 publications

References 0 publications

Surveillance of patients with inflammatory bowel disease

Surveillance of patients with inflammatory bowel disease

Systematic review with network meta‐analysis: endoscopic techniques for dysplasia surveillance in inflammatory bowel disease

Editorial: Clarity and Caution in the Natural History of Low-Grade Dysplasia in Ulcerative Colitis

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