44. (—)Phenylmethoxyacetonitrile

Spectrofluorometric Analysis of Cardiotonic Steroids

“…Bellet (1950) and Sasakawa (1959) have shown that the bluish-green fluorescent product of acid treatment of gitoxin is the A14, A16-dianhydro derivative of gitoxigenin. On the other hand, treatment of digitoxin and digoxin with concentrated hydrochloric acid yields the As,(14) anhydro compounds (Smith, 1935;Smith, 1936) which also fluoresce, according to our results. Thus it would appear that the orientation of the double bond at position 14 is not critical to the development of fluorescence.…”

“…THE dehydration of the cardiotonic steroids by treatment with strong acids or oxidising agents has long been recognised (Jacobs and Collins, 1924;Smith, 1935;Smith, 1936). Petit (1950) showed that the unsaturated anhydrogitoxigenin resulting from phosphoric acid treatment of gitoxin emitted fluorescence under ultra-violet irradiation which could be utilised for the quantitative estimation of the glycoside.…”

Kinetics of the hydrobromination of 10-undecenoic acid

“…The aim of this work is to present our experimental investigations on the kinetics of this hydrobromination reaction. This reaction was carried out in the past by various investigators (Walker and Lumsden, 1901;Smith, 1935; Urshibara and Takebayashi, 1938;Jones, 1947;Socíete Orgánico, 1957; Adamek and Scheiber, 1959) using different experimental conditions.…”

Synthetic approaches toward 12,13-epoxytrichothecenes

“…The method of Conia and Limasset (ggP^CHgl", ;t-AmOK, toluene, 115°C) (96) appears to work well with very hindered ketones (e^.g^., camphor). The recent report of Smith and Jerris indicated that this procedure worked on a system which failed to react under the conditions developed by Welch ât ii" (95). Attempts are underway to apply this methodology to keto alcohol 108.…”