4. Technology overview/Overview of the devices

Fekete, Melinda; Glasnov, Toma N.

doi:10.1515/9783110289169.95

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…Finally, flow chemistry also has the potential to overcome these problems and increase the productivity of biotransformations. − The benefits of immobilized catalysts can be further exploited in continuous flow, in terms of the ease of separation and reuse of the catalyst . One method commonly used when employing immobilized catalysts in a continuous system is a packed bed reactor . In this mode the reagent solution is flowed through a reactor chamber that is filled with the immobilized catalyst.…”

Section: Introductionmentioning

confidence: 99%

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Hugentobler

Rasparini²,

Thompson

et al. 2017

Org. Process Res. Dev.

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In this study a batch reactor process is compared to a flow chemistry approach for lipase catalysed resolution of the cyclopropyl ester (±)-3. (1R, 2R)-3 is a precursor of the amine (1R, 2S)-2 which is a key building block of the API ticagrelor. For both flow and batch operation, the biocatalyst could be recycled several times, whereas in the case of the flow process the reaction time was significantly reduced.2

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Section: Introductionmentioning

confidence: 99%

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Hugentobler

Rasparini²,

Thompson

et al. 2017

Org. Process Res. Dev.

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Chemistry‐Related Innovations in Space, Benefits of Flow Chemistry

Darvas¹,

Mezey

Dormán

et al. 2022

In‐Space Manufacturing and Resources

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Towards More Efficient, Greener Syntheses through Flow Chemistry

Lummiss

Morse

Beingessner

et al. 2017

The Chemical Record

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Technological advances have an important role in the design of greener synthetic processes. In this Personal Account, we describe a wide range of thermal, photochemical, catalytic, and biphasic chemical transformations examined by our group. Each of these demonstrate how the merits of a continuous flow synthesis platform can align with some of the goals put forth by the Twelve Principles of Green Chemistry. In particular, we illustrate the potential for improved reaction efficiency in terms of atom economy, product yield and reaction rates, the ability to design synthetic process with chemical and solvent waste reduction in mind as well as highlight the benefits of the real-time monitoring capabilities in flow for highly controlled synthetic output.

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4. Technology overview/Overview of the devices

Cited by 4 publications

References 40 publications

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Comparison of a Batch and Flow Approach for the Lipase-Catalyzed Resolution of a Cyclopropanecarboxylate Ester, A Key Building Block for the Synthesis of Ticagrelor

Chemistry‐Related Innovations in Space, Benefits of Flow Chemistry

Towards More Efficient, Greener Syntheses through Flow Chemistry

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