Chemistry‐Related Innovations in Space, Benefits of Flow Chemistry

Darvas, Ferenç; Mezey, Paul G.; Dormán, György; Buchholcz, Balázs; Janáky, Csaba; Jones, Richard V.; Sipos, Gellért; Peidl, Tamás; Mezohegyi, Gergo

doi:10.1002/9783527830909.ch6

Cited by 3 publications

(3 citation statements)

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“…Space chemistry 35,36 under microgravity opens unique opportunities to develop new and more efficient drugs used both in space and on Earth. Microgravity could produce unique drug forms, including crystals that grow larger with more regular morphology and provide more stable proteins or other chemical entities of therapeutic relevance.…”

Section: Discussionmentioning

confidence: 99%

Repetitive stability study of Remdesivir/Cyclodextrin complex on ISS

Dormán,

Buchholcz,

Puskás

et al. 2024

Preprint

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Stability assessment of drugs in space is particularly important for future missions., In space there are multiple factors, such as the variability of the conditions (radiation, microgravity, vacuum etc.) that could affect the reliability and reproducibility of the data. Therefore, we investigated the stability of an anti-Covid drug formulation, Remdesivir (RDV) sulfobutylether-beta-cyclodextrin (SBECD) complex, in two separate flight experiments on the International Space Station (ISS). While HPLC/MS studies revealed no degradation of the cyclodextrin excipient in any of the samples investigated in both missions, RDV purity analysis of the RDV/SBECD complex after the first mission revealed different stabilities and altered degradation in space and on Earth. This latter interesting finding was not supported by the second mission, where no differences in the drug stabilities were identified. This anomaly highlighted the importance of standardization together with increased control of the variable parameters during the entire space missions and the terrestrial control experiments.

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Section: Discussionmentioning

confidence: 99%

Repetitive stability study of Remdesivir/Cyclodextrin complex on ISS

Dormán,

Buchholcz,

Puskás

et al. 2024

Preprint

Self Cite

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“…Another example is iron oxide nanoparticles, allowing to design drug delivery systems controlled by an external magnetic field 8 . Zeolites are crystalline aluminosilicates gathering more than 250 identified structures, with five of them being key players in the industry gathering sorption, laundry, catalysis, up to the lenses of the Range Rover robot 9 on March. Zeolites are obtained from the self-assembly of aluminate and silicate precursors around a structure directing agent (SDA) driving the formation of cavities, channels and cages with regular dimensions.…”

Section: Introductionmentioning

confidence: 99%