(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators

Receptor binding activity X 0280(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone Derivatives as Vasopressin Receptor Modulators. -Compounds (I) show binding affinity for the AVP V1a and V2 receptors. (Ib), which exhibits a poor affinity for V2, has the highest diuretic effect among all derivatives. -(VENKATESAN*, A. M.; GROSU, G. T.; FAILLI, A. A.; CHAN, P. S.; COUPET, J.; SAUNDERS, T.; MAZANDARANI, H.; RU, X.; Bioorg. Med. Chem. Lett. 15 (2005) 22, 5003-5006; Chem. Screening Sci., Wyeth Res., Pearl River, NY 10965, USA; Eng.) -C. Oppel

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(4‐Substituted‐phenyl)‐(5H‐10,11‐dihydro‐pyrrolo[2,1‐c] [1,4]benzodiazepin‐10‐yl)‐methanone Derivatives as Vasopressin Receptor Modulators.

Venkatesan

Grosu

Failli

et al. 2006

ChemInform

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Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V2 receptor agonists

Tsukamoto

Koshio

Akamatsu

et al. 2008

Bioorganic & Medicinal Chemistry

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Synthesis and structure–activity relationships of amide derivatives of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetic acid as selective arginine vasopressin V2 receptor agonists

Tsukamoto

Koshio

Kuramochi

et al. 2009

Bioorganic & Medicinal Chemistry

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(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators

Cited by 12 publications

References 12 publications