(4‐Substituted‐phenyl)‐(5H‐10,11‐dihydro‐pyrrolo[2,1‐c] [1,4]benzodiazepin‐10‐yl)‐methanone Derivatives as Vasopressin Receptor Modulators.

Abstract

Receptor binding activity X 0280(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo[2,1-c][1,4]benzodiazepin-10-yl)-methanone Derivatives as Vasopressin Receptor Modulators. -Compounds (I) show binding affinity for the AVP V1a and V2 receptors. (Ib), which exhibits a poor affinity for V2, has the highest diuretic effect among all derivatives. -(VENKATESAN*, A. M.; GROSU, G. T.; FAILLI, A. A.; CHAN, P. S.; COUPET, J.; SAUNDERS, T.; MAZANDARANI, H.; RU, X.; Bioorg. Med. Chem. Lett. 15 (2005) 22, 5003-5006; Chem. Screening Sci., Wyeth Res., Pearl River, NY 10965, USA; Eng.) -C. Oppel