2000
DOI: 10.1002/(sici)1521-3773(20000417)39:8<1453::aid-anie1453>3.0.co;2-7
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4-(N-Methylhydrazino)-7-nitro-2,1,3-benzooxadiazole (MNBDH): A Novel Fluorogenic Peroxidase Substrate

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Cited by 18 publications
(13 citation statements)
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“…The optimization is therefore the first and necessary step in the development of sensors using new peroxidase substrates. MNBDH was first used as a substrate for horseradish peroxidase by Meyer et al [ 22 ]. This compound is nonfluorescent as a hydrazine derivative, but it can be oxidized by H 2 O 2 in the presence of HRP or DNAzyme to N -methyl-4-amino-7-nitrobezofurazan (MNBDA), as shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…The optimization is therefore the first and necessary step in the development of sensors using new peroxidase substrates. MNBDH was first used as a substrate for horseradish peroxidase by Meyer et al [ 22 ]. This compound is nonfluorescent as a hydrazine derivative, but it can be oxidized by H 2 O 2 in the presence of HRP or DNAzyme to N -methyl-4-amino-7-nitrobezofurazan (MNBDA), as shown in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…The reason is its slow conversion by horseradish peroxidase (POD), which allows the use of MNBDH as a substrate only in those cases when POD is present in excess concentrations. Therefore, the determination of hydrogen peroxide, glucose or glucose oxidase leads to favorable analytical figures of merit [27], while the attempt to detect POD itself does not. More recently, it was found that, actually, MNBDH may rapidly be converted by microperoxidases [24].…”
Section: Resultsmentioning
confidence: 99%
“…The dimer is highly fluorescent and has already been used for the detection of several different hydroperoxides. [12][13][14] Especially for TATP, where the LOD of the pHPAA method is by one decade lower than that of the ABTS method, this variation is attractive, although a more complex and time-consuming experimental setup has to be used.…”
Section: Resultsmentioning
confidence: 99%