4-Hydroxypyrazolo (3,4-d) Pyrimidine (HPP) in the Treatment of Gout: Preliminary Observations

Allopurinol in treatment of gout.

“…The results from the present study confirm earlier reports of the effectiveness of allopurinol in the treatment of gout (Rundles et al, 1963 ;Hall et al, 1964 ;Yu and Gutman, 1964;Klinenberg, Goldfinger, and Seegmiller, 1965;Delbarre, Auscher, Labrousse, and de Gery, 1965;Houpt, 1965;Smyth, 1965;Rundles, Metz, and Silberman, 1966), and indicate that the drug maintains its action over a prolonged period. Case 1 above has been taking allopurinol for more than two years, with sustained clinical improvement.…”

“…However, although Klinenberg et al (1965) did not find any consistent change in overall purine excretion during allopurinol therapy, the experience of most others (Rundles et al, 1963 Yu andGutman, 1964;Krakoff and Meyer, 1965) and of ourselves (Hall et al, 1964) indicates that the combined increase of xanthine and hypoxanthine in the urine is usually much smaller than the accompanying decline of urinary uric acid. This may be due either to additional inhibition of an earlier stage of purine metabolism or to re-utilization of xanthine and hypoxanthine.…”

Probenecid, nephrotic syndrome, and renal failure.

“…There has been no recurrence of oedema, and no more than a trace of proteinuria. *This aspect of the case has already been reported in detail (Hall, Holloway, and Scott, 1964; Case 1). Case 2, a bank messenger, had previously had several other occupations but none involving exposure to industrial chemicals.…”

Gout treatment: What is evidence-based and how do we determine and promote optimized clinical care?

“…There have been numerous studies evaluating the efficacy and toxicity of allopurinol in the treatment of chronic gout [50][51][52][53][54][55][56][57][58][59][60][61][62]. These studies have universally shown a significant urate-lowering effect associated with its use.…”