4-Carboxyphenylboronic acid-decorated, redox-sensitive rod-shaped nano-micelles fabricated through co-assembling strategy for active targeting and synergistic co-delivery of camptothecin and gemcitabine

Xu, Yanyun; Huang, Yushu; Lü, Wei; Liu, Shiyuan; Xiao, Yi; Yu, Jiahui

doi:10.1016/j.ejpb.2019.09.019

Cited by 16 publications

(9 citation statements)

References 45 publications

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“…Xu et al. ( 2019b ) prepared redox-sensitive rod-like micelles by co-assembly of CPT-disulfide bond-PEG2000-4-carboxyphenylboronic acid and CPT-disulfide bond-GEM to achieve controllable redox and tumor-targeted synergistic self-delivery of CPT and GEM. In vitro drug release studies verified the redox triggering and synchronous rapid release of CPT and GEM by the co-assembled nano micelles.…”

Section: Types and Characteristics Of Ndcdsmentioning

confidence: 99%

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Shao

et al. 2022

Drug Delivery

103

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Chemotherapy drugs have been used for a long time in the treatment of cancer, but serious side effects are caused by the inability of the drug to be solely delivered to the tumor when treating cancer with chemotherapy. Natural products have attracted more and more attention due to the antitumor effect in multiple ways, abundant resources and less side effects. Therefore, the combination of natural active ingredients and chemotherapy drugs may be an effective antitumor strategy, which can inhibit the growth of tumor and multidrug resistance, reduce side effects of chemotherapy drugs. Nano-drug co-delivery system (NDCDS) can play an important role in the combination of natural active ingredients and chemotherapy drugs. This review provides a comprehensive summary of the research status and application prospect of nano-delivery strategies for the combination of natural active ingredients and chemotherapy drugs, aiming to provide a basis for the development of anti-tumor drugs.

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Section: Types and Characteristics Of Ndcdsmentioning

confidence: 99%

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Shao

et al. 2022

Drug Delivery

103

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“…The results demonstrated that the combination of receptor-mediated targeting and environment-mediated targeting enhanced 4B). 4 CPBA-modified coassembled nanomicelles have significantly enhanced cellular internalization, while the cellular uptake of free CPBA pretreated cells was significantly reduced. The results proved the active targeting ability of the PBA-mediated synergistic assembly of nanomicelles.…”

Section: Tumor Therapymentioning

confidence: 96%

“…The hydrophilic PEG was generally chosen to react with PBA, and PBA-based functional materials were obtained by self-assembly. For instance, camptothecin–disulfide bond–PEG2000–4-carboxybenzoic acid was self-assembled to form nanomicelles as an active targeting and redox-sensitive pro-drug, and the nanomicelles achieved disulfide-bond-triggered drug release in the tumor microenvironment with high glutathione concentration. Similarly, Zhang et al developed a multifunctional star micelle system by simply mixing photoinitiated cross-linked amphiphilic copolymers with ligand-bound redox-sensitive amphiphilic copolymers .…”

Section: Modification Of Pba On Functional Chemical Materialsmentioning

confidence: 99%

Phenylboronic-acid-based Functional Chemical Materials for Fluorescence Imaging and Tumor Therapy

Hou

et al. 2022

ACS Omega

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Various functional chemical materials have been widely used in imaging and tumor therapy. Targeted ligands such as antibodies, peptides, and small molecules have been combined with functional materials to enhance cellular uptake and are used for active targeting of cancer cells and tumors. Among them, phenylboronic acid (PBA), as a small molecular ligand, has the characteristics of low cytotoxicity and easy modification. PBA improves the cancer cell imaging and tumor treatment effect by binding to glycans on the surface of cancer cells. In this Mini-Review, we introduced the modification strategy and targeting strategy of PBA. We focused on the applications of PBA-based functional materials in fluorescence imaging and tumor therapy. For fluorescence imaging, the potential of PBA-based functional chemical materials in cancer diagnosis and tumor targeting was proved by cell imaging and in vivo imaging. For tumor therapy, we mainly discussed the applications of PBA-based functional chemical materials in chemotherapy, gene therapy, phototherapy, and immunotherapy. PBA-based functional chemical materials provide a useful method for cancer diagnosis and treatment.

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“…Synthesis of PBA-PEG-COOH. PEG was modified by similar protocol according to the previous study [27]. 10 mL of DMSO was added appropriately to dissolve 0.2 g of DMAP, 0.4 g of EDCI, and 0.4 g of PBA.…”

Section: Combination Therapy Of Free Dox and Pf In Vitromentioning

confidence: 99%

Codelivery of Doxorubicin/PI3K Inhibitor Nanomicelle Linked with Phenylboronic Acid for Enhanced Cytotoxicity to Pancreatic Cancer

Zeng

Fan

et al. 2022

Journal of Nanomaterials

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Multidrug combination therapy for pancreatic cancer is widely applied in clinical practice. In this study, we used phenylboronic acid and polyethylene glycol as materials of nanomicelles, loaded with the PI3K/mTORC1 dual inhibitor PF04691502 (PF) to inhibit the resistance and metastasis of pancreatic cancer and increase the sensitivity of doxorubicin (DOX). We prepared the PPD nanoparticles (NPs) with a small PDI and a uniform morphology by controlling the DOX substitution degree (size of 164.8 ± 3.6 nm and zeta potential of − 16.9 ± 0.4 mV). We determined the rates of PF and materials through the combination experiment of free drugs and the obtained PF@PPD NPs (size of 200.8 ± 2.6 nm and zeta potential of − 13.9 ± 0.3 mV). The drug loadings of DOX and PF in the nanomicelle were 14.8 ± 0.4 % and 9.5 ± 0.3 % , respectively. And the drug release in vitro was slow ( 29.17 ± 2.00 % for DOX and 39.22 ± 2.49 % for PF). The cell assay showed that the NPs had a good curative effect and migration on BxPC-3 cells, and it could be continuously taken up by cells. The PF@PPD NPs displayed a dose-dependent cytotoxicity with less cell viability ( 20.38 ± 1.11 % ) and higher uptake in BxPC-3 cells compared with the free drug. The combined medication or PF@PPD NPs reduced tumor metastasis, indicating that PF@PPD NPs had the potential for clinical application.

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4-Carboxyphenylboronic acid-decorated, redox-sensitive rod-shaped nano-micelles fabricated through co-assembling strategy for active targeting and synergistic co-delivery of camptothecin and gemcitabine

Cited by 16 publications

References 45 publications

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review

Phenylboronic-acid-based Functional Chemical Materials for Fluorescence Imaging and Tumor Therapy

Codelivery of Doxorubicin/PI3K Inhibitor Nanomicelle Linked with Phenylboronic Acid for Enhanced Cytotoxicity to Pancreatic Cancer

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