4 Anti-Ulcer Drugs of Plant Origin

Lewis, David; Hanson, Peter J.

doi:10.1016/s0079-6468(08)70365-5

Cited by 146 publications

(133 citation statements)

References 42 publications

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“…Therefore, there might be a synergistic effect among the triterpenes present in these crude extracts, allowing the use of these plants only as phytotherapeutic crude preparations for the treatment of gastric ulcer. Moreover, previous studies have shown that some terpenes or their derivatives, isolated from higher plants, display in vivo antiulcerogenic activity (Rodriguez et al, 2002(Rodriguez et al, , 2003Lewis and Hanson, 1991).The active compounds, comprising sesquiterpenes, diterpenes and triterpenes seem to act by different and complementary mechanisms, exhibiting as common feature an improvement of the mucosal defensive factors more than the effects on the aggressive factors (Hiruma-Lima et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Antiulcerogenic Activity of Crude Extract, Fractions and Populnoic Acid Isolated from Austroplenckia populnea (Celastraceae)

Andrade

Antoniolli

Comunello

et al. 2006

Zeitschrift Für Naturforschung C

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Many plant crude extracts and their isolated compounds are the most attractive sources of new drugs and show promising results for the treatment of gastric ulcers. Austroplenckia populnea is commonly known as "marmelinho-do campo, mangabeira-brava, mangabarana and vime" and it has been used in folk medicine as anti-dysenteric and anti-rheumatic. Powdered bark wood (3.25 kg) was macerated with aqueous ethanol (96%) and the extract was concentrated under reduced pressure to yield 406 g of crude hydralcoholic extract. The hydralcoholic extract was suspended in aqueous methanol and partitioned with hexane, chloroform and ethyl acetate (EtOAc) in sequence, yielding 8.0 g, 9.5 g and 98.17 g of crude extracts, respectively. Chromatography of the hexane extract over a silica gel column led to the isolation of the triterpene populnoic acid. The oral administration of hydralcoholic, hexane, chloroform and EtOAc extracts (200 mg/kg) decreased the ulcer lesion index (ULI) by 83.15%, 46.87%, 32.2%, 68.12%, respectively. Oral administration of populnoic acid (100 mg/ kg) diminished the ULI by 55.29%. All the obtained results were significant in comparison with the negative control, with exception of the chloroform extract.

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Section: Discussionmentioning

confidence: 99%

Antiulcerogenic Activity of Crude Extract, Fractions and Populnoic Acid Isolated from Austroplenckia populnea (Celastraceae)

Andrade

Antoniolli

Comunello

et al. 2006

Zeitschrift Für Naturforschung C

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“…Saponins, especially triterpenes type have been implicated in antiulcer activity mediated by formation of protective mucus on the gastric mucosa and also protect the mucosa from acid effects by selectively inhibiting prostaglandin F 2a. (PGF2α) (Agwu and Okunji, 1986;Lewis and Hanson, 1991).…”

Section: Discussionmentioning

confidence: 99%

Antiulcerogenic activity of ethanolic leaf extract of <i>Lasianthera africana</i>

Okokon¹,

Antia²,

Umoh³

2010

Afr. J. Trad. Compl. Alt. Med.

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The effect of ethanolic leaf extract of Lasianthera africana on experimentally induced ulcer was studied in rats. The extract (1000 -3000mg/kg) inhibited ethanol-induced, indomethacin -induced and reserpine -induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.01). The effect of the extract was comparable to that of the standard drugs used. Thus, Lasianthera africana extract demonstrated a good antiulcer activity which supports the antiulcer effect of this plant in traditional medicine.

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“…Flavonoids possess antioxidant properties in addition to strengthening the mucosal defense system through stimulation of gastric mucus secretion [30] and flavonoids can scavenge for the reactive oxygen species (superoxide anions) and free radicals produced by ethanol. These reactive intermediates are potentially implicated in ulcerogenicity [31].…”

Section: Renal Function Test Of Rats In Acute Toxicity Study Of Mcelementioning

confidence: 99%

Leaves Extract of Muntingia Calabura Protects Against Gastric Ulcer Induced by Ethanol in Sprague-Dawley Rats

Ibrahim¹

2012

Clinic Experiment Pharmacol

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Aim: Muntingia calabura is a medicinal plant used popularly known in Malaysia against various diseases including peptic ulcer. This study was performed to evaluate the gastroprotective effect of ethanolic extracts of Muntingia calabura Leaf Extract (MCELE) against ethanol-induced gastric mucosal injury in experimental rats. Methods:The rats were divided into four groups respectively pre-treated orally with Carboxymethyl Cellulose (CMC) solution (ulcer control groups), omeprazole 20 mg/kg (reference group), 250 and 500 mg/kg of MCELE (experimental groups) one hour before oral administration of absolute ethanol to generate gastric mucosal damage. After an additional hour, the rats were sacrificed and the ulcerated areas of the gastric walls were determined. Results:The ulcer control group exhibited severe mucosal injury, whereas groups pre-treated with the MCELE exhibited significant protection of gastric mucosa. These findings were also confirmed by histology of the gastric wall. Significant increases in gastric mucus production and decrease in acidity of gastric content were observed in the treated groups with MCELE compare to ulcer control group. Conclusions:The treatment with MCLELE prior to absolute alcohol has significantly protect gastric mucosa as ascertained by significant reduction of ulcer area, increases in gastric mucus production, decrease the acidity of gastric content and histology by comparatively decreases gastric mucosal injury, reduction of oedema and leukocyte infiltration of submucosal layer. MCELE was able to decrease the acidity and increase the mucosal defence in the gastric area, thereby justifying its use as an antiulcerogenic agent.

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4 Anti-Ulcer Drugs of Plant Origin

Cited by 146 publications

References 42 publications

Antiulcerogenic Activity of Crude Extract, Fractions and Populnoic Acid Isolated from Austroplenckia populnea (Celastraceae)

Antiulcerogenic Activity of Crude Extract, Fractions and Populnoic Acid Isolated from Austroplenckia populnea (Celastraceae)

Antiulcerogenic activity of ethanolic leaf extract of <i>Lasianthera africana</i>

Leaves Extract of Muntingia Calabura Protects Against Gastric Ulcer Induced by Ethanol in Sprague-Dawley Rats

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