Antiulcerogenic activity of ethanolic leaf extract of <i>Lasianthera africana</i>

Abstract

The effect of ethanolic leaf extract of Lasianthera africana on experimentally induced ulcer was studied in rats. The extract (1000 -3000mg/kg) inhibited ethanol-induced, indomethacin -induced and reserpine -induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.01). The effect of the extract was comparable to that of the standard drugs used. Thus, Lasianthera africana extract demonstrated a good antiulcer activity which supports the antiulcer effect of this plant in traditional medicine.

Antiplasmodial and antiulcer activities of Melanthera scadens

“…dissolved in distilled water) [15] ; and positive control group (group 5) received cimetidine (100 mg/kg p.o. dissolved in 50% Tween 80); groups 2-4 were pretreated with M. scandens extract (37, 74 and 111 mg/kg p.o., respectively); group 5 received cimetidine (100 mg/kg p.o.…”

Comparative anatomy, nutraceutical potentials and heavy metal composition of two varieties of<i> Lasianthera africana</i> (P. Beauv)

“…L. africana is commonly used as antacid, analgesic, a n t i s p a s m o d i c , l a x a t i v e , a n t i p y r e t i c , antiulcerogenic, antidiabetic and antimalarial (Okokon, et al, 2007). Biological activities reported on Lasianthera africana include bacteriostatic (Itah, 1997), fungicidal (Itah, 1996) antidiabetic (Ekanem, 2006), antiplasmodial (Okokon, et al, 2007), antimicrobial (Andy, et al, 2008) and antiulcer (Okokon, et al, 2009). The leaf extract has been reported to contain alkaloids, terpenes, saponins, tannins, flavonoids, anthraquinones and cardiac glycosides with LD 50 value of 5000 mg/kg (Okokon, et al, 2009).…”

Antiplasmodial and antipyretic effects of ethanol root extract and fractions of Setaria megaphylla (Steud) T. Dur and Schinz (Poaceae)

“…The cytotoxic, immunomodulatory and antileishmanial activities of the ethanol leaf extract of S. megaphylla have been reported [4]. There is little available information about the activities of S. megaphylla roots.…”

“…This results in hyperthermia [4]. DNP causes hyperthermia by uncoupling oxidative phosphorylation resulting in calcium release from mitochondrial stores and preventing calcium reuptake.…”

“…The results of phytochemical screening revealed the presence of flavonoids, deoxy-sugars, terpenes, saponins, tannins, anthraquinones and cardiac glycosides in the root extract [1]. Data from GC-MS studies of n-hexane fraction of the leaves showed that it contained components such as 8,11,14-eicosatrienoic acid (Z,Z,Z), phthalic acid, diisooctyl ester, vitamin E, γ-elemene, Urs-12-ene, bicyclogermacrene, α-muurolene, germacrene-A, and guaiol among others [4].…”