4-Aminophenyl boronic acid modified gold platforms for influenza diagnosis

Di̇ltemi̇z, Sibel Emi̇r; Ersöz, Arzu; Hür, Deniz; Keçili, Rüstem; Say, Rıdvan

doi:10.1016/j.msec.2012.11.007

Cited by 26 publications

(15 citation statements)

References 37 publications

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“…Moreover, an injection of excess insulin could result in a serious shock response, even leading to death, [5,6] so it is very important to develop smart response systems which release insulin according to blood glucose levels. Recently, work on glucose-sensitivity in physiological conditions has been widely reported [7][8][9][10] and includes concanavalin, glucose oxide and phenylboronic acid (PBA) [11], but concanavalin and glucose oxide are both based on proteins and so exhibit certain defects, such as antigenicity, instability and high cost [12][13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of temperature- and glucose-sensitive nanoparticles based on phenylboronic acid and N-vinylcaprolactam for insulin delivery

Bremner

et al. 2016

Materials Science and Engineering: C

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Poly N-vinylcaprolactam-co-acrylamidophenylboronic acid p(NVCL-co-AAPBA) was prepared from N-vinylcaprolactam (NVCL) and 3-acrylamidophenylboronic acid (AAPBA), using 2,2-azobisisobutyronitrile (AIBN) as initiator. The synthesis and structure of the polymer were examined by Fourier Transform infrared spectroscopy (FT-IR) and (1)H-NMR. Dynamic light scattering (DLS), lower critical solution temperature (LCST) and transmission electron microscopy (TEM) were utilized to characterize the nanoparticles, CD spectroscopy was used to determine if there were any changes to the conformation of the insulin, and cell and animal toxicity were also investigated. The prepared nanoparticles were found to be monodisperse submicron particles and were glucose- and temperature-sensitive. In addition, the nanoparticles have good insulin-loading characteristics, do not affect the conformation of the insulin and show low-toxicity to cells and animals. These p(NVCL-co-AAPBA) nanoparticles may have some value for insulin or other hypoglycemic protein delivery.

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Section: Introductionmentioning

confidence: 99%

Synthesis and evaluation of temperature- and glucose-sensitive nanoparticles based on phenylboronic acid and N-vinylcaprolactam for insulin delivery

Bremner

et al. 2016

Materials Science and Engineering: C

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“…After that, QCM electrodes were modified with imide groups by using N-(3dimethylaminopropyl)-N'-ethylcarbodiimide and N-hydroxysuccinimide for immobilization of 4-APBA and SA. After interaction with the samples, the binding capacity and limit of detection of QCM sensors were found to be 4.7×10 -2 μM and 0.26 μM ml -1 , respectively [60].…”

Section: Biosensors -Micro and Nanoscale Applicationsmentioning

confidence: 98%

Molecularly Imprinted Sensors — New Sensing Technologies

Uygun¹,

Uygun²,

Ermiş³

et al. 2015

Biosensors - Micro and Nanoscale Applications

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In this chapter we discus molecular imprinting technology MIT , molecular imprinted polymers MIPs , and their compatibility on a proper transducer to construct a sensing system. Molecularly imprinted sensors MISens , in other words, artificial receptor-based sensors synthesized in the presence of the target molecule, are capable of sensing target molecules by using their specific cavities and are compatible with the target molecule. This MIP technology is a viable alternative of artificial receptor technology, and the sensor technology is capable of detecting any kind of molecule without pre-analytic preparations. In this chapter, you can find examples, sensor construction techniques and fundamentals of MIP and sensor combinations to look forward in your studies. For sensor technology, we explained and discussed the new sensing technologies of MIP-based electrochemical, optical especially surface plasmon resonance, SPR , and piezoelectric techniques. Therefore, this chapter presents a short guideline of MISens.

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“…30.5, they modified the nanosensor surfaces with thiol groups and then immobilized 4-aminophenylboronic acid and sialic acid. Also, they calculated detection limits as 4.7 3 10 22 and 1.28 3 10 21 µM for piezoelectric and optic nanosensors [103].…”

Section: Influenzamentioning

confidence: 99%