4,5-Dichloro-2-octyl-4-isothiazolin-3-one (DCOIT) modifies synaptic transmission in hippocampal CA3 neurons of rats

Wakita, Masahito; Shoudai, Kiyomitsu; Oyama, Yasuo; Akaike, Norio

doi:10.1016/j.chemosphere.2017.05.158

Cited by 3 publications

(1 citation statement)

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“…As a result, DCOIT has broad application prospects in the antifouling industry. DCOIT can easily cross cell membranes and cell walls, resulting in oxidative stress in the cell, and eventually cell necrosis [26]. The toxicity mechanism of DCOIT consists of the formation of free radicals followed by the blockage of the oxidative stress defence system.…”

Section: Introductionmentioning

confidence: 99%

Enhanced antifouling and antibacterial performances of novel UV-curable polysiloxane/microcapsules/Ag composite coatings for marine applications

Liu,

Zheng,

Liu

et al. 2024

R. Soc. Open Sci.

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Marine biological fouling is a widespread phenomenon encountered by various oceanic ships and naval vessels, resulting in enormous economic losses. Herein, novel 4,5-dichloro-2-octyl-isothiazolone@sodium alginate/chitosan microcapsules (DCOIT@ALG/CS) were prepared through composite gel method using DCOIT as core materials, ALG and CS as shells, and CaCl 2 as the cross-linking agent. The formed microcapsules (MCs) with Ag nanoparticles (AgNPs) were then filled in UV-curable polysiloxane (UV-PDMS), followed by UV irradiation to yield UV-PDMS/microcapsules/AgNPs (UV-PDMS/MCs/Ag) composite coatings. The constructed micro–nano dual-scale surface using the MCs and AgNPs improved the antifouling and antibacterial properties of UV-PDMS/MCs/Ag coatings. The as-obtained UV-PDMS/MCs/Ag coatings exhibited a static contact angle of about 160°, shear strength of 2.24 MPa, tensile strength of 3.32 MPa and elongation at break of 212%. The synergistic bacteriostatic effects of DCOIT and AgNPs in UV-PDMS/MCs/Ag coatings resulted in a bactericidal rate of 200 μg ml −1 towards Escherichia coli and Staphylococcus aureus with saturation at 100% within 10 min. In sum, the proposed composite coatings look promising for future marine transportation, pipeline networks and undersea facilities.

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Section: Introductionmentioning

confidence: 99%