4-[2-Allylsulfanyl-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-2-amino-butyric acid: evaluation as topoisomerase inhibitor using in vitro assay and molecular docking study

Pratheebaa, P.; Perumal, Perumal; Angayarkanni, Jayaraman; Narayanan, Shridhar; Palvannan, Thayumanavan

doi:10.1007/s00044-014-1263-y

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…All the enzyme assay kits and protein estimation standard kit were purchased from Coral Clinical systems, Goa, India. SAG was synthesized as described previously [23].…”

Section: Chemicals and Kitsmentioning

confidence: 99%

“…SAG is a synthetic analogue of GSH. Our lab, as well as other groups, has reported various biological activities of SAG such as enhancing antioxidants, decreasing oxidative stress, anti-inflammatory effect and mitochondrial protection in liver and brain against different toxicities such as carbon tetrachloride and lipopolysaccharides, respectively [22][23][24][25]. However, biological efficacy of SAG-Sh-SeNPs to defeat oxidative stress or any other pathological condition has not been studied till date.…”

Section: Introductionmentioning

confidence: 99%

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Green synthesized selenium nanoparticles using Spermacoce hispida as carrier of s-allyl glutathione: to accomplish hepatoprotective and nephroprotective activity against acetaminophen toxicity

Vennila

Loganathan

Palvannan

2019

Artificial Cells, Nanomedicine, and Biotechnology

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s-allyl glutathione (SAG) an analogue of glutathione is explored for its antioxidative and liver protection property in recent years. Selenium nanoparticles (Sh-SeNPs) were synthesized using medicinal plant Spermacoce hispida and conjugated with SAG (SAG-Sh-SeNPs). SAG-Sh-SeNPs and Sh-SeNPs were characterized using by Fourier transform infrared spectroscopy, Transmission electron microscopy, Energy dispersive X-ray analysis, X-ray diffraction analysis and zeta potential analysis. SAG-Sh-SeNPs and Sh-SeNPs were evaluated against acetaminophen (APAP)-induced liver and kidney injury in rat. Pretreatment of NPs attenuated the APAP toxicity-induced elevation of kidney and liver injury markers in the blood circulation. Histological observation showed that NPs pretreatment protected the morphology of liver and kidney tissue. SAG-Sh-SeNPs showed enhanced protection against APAP toxicity in comparison to Sh-SeNPs due to synergistic effect of SAG and Sh-SeNPs. SAG-Sh-SeNPs protected the liver and kidney against APAP toxicity through reducing oxidative stress, enhancing endogenous antioxidants and protecting mitochondrial functions.

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“…All the enzyme assay kits and protein estimation standard kit were purchased from Coral Clinical systems, Goa, India. SAG was synthesized as described previously [23].…”

Section: Chemicals and Kitsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Green synthesized selenium nanoparticles using Spermacoce hispida as carrier of s-allyl glutathione: to accomplish hepatoprotective and nephroprotective activity against acetaminophen toxicity

Vennila

Loganathan

Palvannan

2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…The synthetic sequence for γ-glutamyl tripeptides as represented by the preparation of γ-L-glutamyl-S-methyl-L-cysteinylglycine (S-methylglutathione, 9) is shown in Figure 4, route 3. 48,49) After the methylation of reduced glutathione (1), the pH of the solution was adjusted to 2-3 with concentrated hydrochloric acid, and the crystallized material was desalted and purified by loading onto an ion exchange resin (Dowex 1-acetate) followed by elution with 1N acetic acid. γ-L-Glutamyl-S-methyl-L-cysteinylglycine sulfoxide (Smethylglutathione sulfoxide, 16) was obtained by the treatment of compound 9 with approximately 1.2 equivalents of 2% aqueous H2O2.…”

Section: Synthesis Of Peptidesmentioning

confidence: 99%

Structural analysis and taste evaluation of γ-glutamyl peptides comprising sulfur-containing amino acids

Amino

Wakabayashi

Akashi

et al. 2018

Bioscience, Biotechnology, and Biochemistry

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The structures, flavor-modifying effects, and CaSR activities of γ-glutamyl peptides comprising sulfur-containing amino acids were investigated. The chemical structures, including the linkage mode of the N-terminal glutamic acid, of γ-L-glutamyl-S-(2-propenyl)-L-cysteine (γ-L-glutamyl-S-allyl-L-cysteine) and its sulfoxide isolated from garlic were established by comparing their NMR spectra with those of authentic peptides prepared using chemical methods. Mass spectrometric analysis also enabled determination of the linkage modes in the glutamyl dipeptides by their characteristic fragmentation. In sensory evaluation, these peptides exhibited flavor-modifying effects (continuity) in umami solutions less pronounced but similar to that of glutathione. Furthermore, the peptides exhibited intrinsic flavor due to the sulfur-containing structure, which may be partially responsible for their flavor-modifying effects. In CaSR assays, γ-L-glutamyl-S-methyl-L-cysteinylglycine was most active, which indicates that the presence of a medium-sized aliphatic substituent at the second amino acid residue in γ-glutamyl peptides enhances CaSR activity.

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S-allyl-glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: Focus towards anti-oxidative efficiency

Palvannan

Loganathan

Iruthayaraj

et al. 2018

Environmental Toxicology and Pharmacology

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4-[2-Allylsulfanyl-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-2-amino-butyric acid: evaluation as topoisomerase inhibitor using in vitro assay and molecular docking study

Cited by 6 publications

References 24 publications

Green synthesized selenium nanoparticles using Spermacoce hispida as carrier of s-allyl glutathione: to accomplish hepatoprotective and nephroprotective activity against acetaminophen toxicity

Green synthesized selenium nanoparticles using Spermacoce hispida as carrier of s-allyl glutathione: to accomplish hepatoprotective and nephroprotective activity against acetaminophen toxicity

Structural analysis and taste evaluation of γ-glutamyl peptides comprising sulfur-containing amino acids

S-allyl-glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: Focus towards anti-oxidative efficiency

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