3β, 22-Dihydroxylanosta-7,9(11), 24-triene: A New, Minor Compound fromInonotus obliquus

Abstract

The present paper deals with the isolation and structural elucidation of a new triterpene diol with the lanostane skeleton. The structure of the compound was confirmed to be 3beta, 22-dihydroxylanosta-7,9(11), 24-triene on the basis of spectroscopic data.

Chemical Constituents from Inonotus obliquus and Their Biological Activities

“…1 (C-11)] in the 1 H NMR (Table 1) indicated that 3 possessed a 7,9(11)-diene moiety. 11 The two oxymethine protons [δ H 4.76 (m) 1α,3β,21α,25,28-pentahydroxy-5α-lanosta-7,9(11)-diene. To our knowledge, a lanostane triterpene having a 1α,3β-dihydroxy moiety has rarely been isolated from I. obliquus.…”

“…In Russia and western Siberia, this mushroom has been used in folk medicine for cancer treatment for more than four centuries. − Recently, the extract of this fungus was reported to possess antitumor, antioxidant, and anti-inflammatory activities . Previous phytochemical studies on I. obliquus have shown that this fungus is rich in triterpenes. ,− …”

Terpenoids with alpha-glucosidase inhibitory activity from the submerged culture of Inonotus obliquus

“…The other four known compounds were identified as inotodiol (3) (Du et al, 2011), 3b,22-dihydroxyanosta-7,9(11),24-triene (4) (Kahlos and Hiltunen, 1986;Quang et al, 2002), 3b-hydroxycinnamolide (7) (Ayer and Trifonov, 1992), and 17-hydroxy-ent-atisan-19-oic acid (8) (Du et al, 2004) by comparing their spectroscopic data with those reported in the literature.…”

Inhibitory Effects of Chaga (Inonotus Obliquus) on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis

“…Since the sixteenth century, the sclerotia of Inonotus obliquus (Hymenochaetaceae), chaga, have been used as a folk medicine for cancer [7]. Recently, it has been reported that chaga contains triterpenoids [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] and phenolics [27][28][29]. On the other hand, we found that lanostane-type triterpenoids inhibit tumor promotion in mouse skin two-stage carcinogenesis [4,5].…”