Inhibitory Effects of Chaga (Inonotus Obliquus) on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis

medicine extracts that have been anticipated for their cancer prevention effects [1]. In this chapter, we will introduce the anticancer activities of polysaccharides as well as the cancer prevention activities of sterols and triterpenes. 2. Mushroom-derived anticancer polysaccharides Research on mushroom-derived β-glucans began when Chihara, Hamuro, and others at the National Cancer Center Research Institute in Japan isolated and purified lentinan, a β-1,3glucan with branched chains formed by β-1,6-glycosidic bonds, from L. edodes in 1968 [2, 3]. Subsequently, many efficacy studies on lentinan, primarily concerning its antitumor activities, have been reported [4-6]. Ikekawa et al. intraperitoneally administered aqueous extracts of six types of edible mushrooms, and demonstrated their antitumor effects on cancer cell line sarcoma S-180 [7]. Upon such discoveries, polysaccharides lentinan and schizophyllan, glycoprotein krestin, and P. linteus mycelia extract meshima have been utilized as anticancer drugs.

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Inhibitory Effects of Leaves of Guava (Psidium guajava) on TPA-Induced Inflammation and Tumor Promotion in Two-Stage Carcinogenesis in Mouse Skin

Yasukawa

Kakegawa

2015

J. Pharm. Nutr. Sci.

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Cancer prevention offers the most cost-effective long-term health strategy. The methanol extract of the leaves of guava(Psidium guajava) exhibits marked antitumor activity in an in vivo two-stage carcinogenesis test in mice using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and 12-O-tetradecanoylphorbol-13- acetate (TPA) as a promoter. From the active fraction of the methanol extract, five triterpene acids, uvaol (1), ursolic acid (2), corosolic acid (3), asiatic aci (4), and oleanolic acid d (5), were isolated and identified. These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 µg/ear) in mice, and showed marked anti-inflammatory effects, with a 50% inhibitory dose of 117–657 nmol/ear. The leaves of guava may therefore be effective for cancer prevention.

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Inhibitory Effects of Chaga (Inonotus Obliquus) on Tumor Promotion in Two-Stage Mouse Skin Carcinogenesis

Cited by 3 publications

References 29 publications

Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells

Lanostane-type triterpenes from the sclerotium of Inonotus obliquus (Chaga mushrooms) as proproliferative agents on human follicle dermal papilla cells

Edible and Medicinal Mushrooms as Promising Agents in Cancer

Inhibitory Effects of Leaves of Guava (Psidium guajava) on TPA-Induced Inflammation and Tumor Promotion in Two-Stage Carcinogenesis in Mouse Skin

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