3D silicon microdosimetry and RBE study using <sup>12</sup>C ion of different energies

Tran, Linh T.; Chartier, Lachlan; Bolst, David; Prokopovich, Dale A.; Guatelli, Susanna; Petasecca, Marco; Lerch, Michael L. F; Reinhard, Mark I.; Perevertaylo, Vladimir; Jackson, Michael; Matsufuji, Naruhiro; Hinde, David; Dasgupta, M.; Stuchbery, A. E.; Rosenfeld, Anatoly

doi:10.1088/1742-6596/777/1/012037

Cited by 11 publications

(22 citation statements)

References 6 publications

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“…The SOI microdosimeter in this study is an array of 3D SVs with size 30 × 30 × 10 μm 3 , fabricated on a high resistivity 10‐μm‐thick n‐SOI active layer, bonded to a 400‐μm‐thick low‐resistivity supporting wafer. The well‐defined 3D SVs has uniform charge collection . SOI microdosimeters, in contrast to the TEPCs, provide high spatial resolution necessary where particle LET varies significantly over a short distance, e.g., toward the end of the BP.…”

Section: Methodsmentioning

confidence: 99%

“…Recently, the CMRP has developed and fabricated SOI microdosimeters consisting of micron‐sized well‐defined 3D SVs known as “bridge” microdosimeters. The device was previously characterized in detail and successfully applied in 12 C ion therapy at HIMAC, Japan . Using this microdosimeter, we were able to measure the microdosimetric quantity

\bar{y_{D}}

, which was used as an input parameter for the MKM to calculate the RBE 10 corresponding to 10% of human salivary gland (HSG) cell survival.…”

Section: Introductionmentioning

confidence: 99%

“…The device was previously characterized in detail and successfully applied in 12 C ion therapy at HIMAC, Japan. 24,25 Using this microdosimeter, we were able to measure the microdosimetric quantity y D, which was used as an input parameter for the MKM to calculate the RBE 10 corresponding to 10% of human salivary gland (HSG) cell survival. The corresponding biological doses (RBE 10 xD) in-field and out-of-field were obtained with submillimeter spatial resolution and compared to TEPC measurements.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid‐state microdosimeter

et al. 2017

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The SOI microdosimeter with its well-defined 3D SV has applicability in characterizing proton radiation fields and can measure relevant physical parameters to model the RBE with submillimeter spatial resolution. It has been shown that for a physical dose of 1.82 Gy at the BP, the derived RBE based on the MKM model increased from 1.14 to 1.6 in the BP and its distal part. Good agreement was observed between the experimental and simulation results, confirming the potential application of SOI microdosimeter with 3D SV for quality assurance in proton therapy.

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Section: Methodsmentioning

confidence: 99%

\bar{y_{D}}

, which was used as an input parameter for the MKM to calculate the RBE 10 corresponding to 10% of human salivary gland (HSG) cell survival.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid‐state microdosimeter

et al. 2017

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“…Calibration of MCA channel number to energy was performed using a calibrated pulse generator. The pulse generator was calibrated to a 300 μm thick planar, silicon, fully depleted PIN diode in response to 5.486 MeV alpha particles from an Am‐241 source . This calibration approach was facilitated by the linear response of the MicroPlus probe.…”

Section: Methodsmentioning

confidence: 99%

Microdosimetric measurements of a clinical proton beam with micrometer‐sized solid‐state detector

et al. 2017

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Purpose: Microdosimetry is a vital tool for assessing the microscopic patterns of energy deposition by radiation, which ultimately govern biological effect. Solid-state, silicon-on-insulator microdosimeters offer an approach for making microdosimetric measurements with high spatial resolution (on the order of tens of micrometers). These high-resolution, solid-state microdosimeters may therefore play a useful role in characterizing proton radiotherapy fields, particularly for making highly resolved measurements within the Bragg peak region. In this work, we obtain microdosimetric measurements with a solid-state microdosimeter (MicroPlus probe) in a clinical, spot-scanning proton beam of small spot size. Methods: The MicroPlus probe had a 3D single sensitive volume on top of silicon oxide. The sensitive volume had an active cross-sectional area of 250 lm 9 10 lm and thickness of 10 lm. The proton facility was a synchrotron-based, spot-scanning system with small spot size (r % 2 mm). We performed measurements with the clinical beam current (%1 nA) and had no detected pulse pile-up. Measurements were made in a water-equivalent phantom in water-equivalent depth (WED) increments of 0.25 mm or 1.0 mm along pristine Bragg peaks of energies 71.3 MeV and 159.9 MeV, respectively. For each depth, we measured lineal energy distributions and then calculated the dose-weighted mean lineal energy, y D . The measurements were repeated for two field sizes: 4 9 4 cm 2 and 20 9 20 cm Conclusions: We performed microdosimetric measurements with a novel solid-state, silicon-oninsulator microdosimeter in a clinical spot-scanning proton beam of small spot size and unmodified beam current. For all of the proton field sizes and energies considered, the measurements of y D were in agreement with expected trends. Furthermore, we obtained measurements with a spatial resolution of 10 lm in the beam direction. This spatial resolution greatly exceeded that possible with a conventional gaseous tissue-equivalent proportional counter and allowed us to perform a high-resolution investigation within the Bragg peak region. The MicroPlus probe is therefore suitable for applications in proton radiotherapy.

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“…The derived RBE 10 value at the peak value is 2.6 for the broad‐beam case and it is in a good agreement with the value derived earlier using a Bridge microdosimeter in a water phantom for the same carbon ion beam delivery conditions at HIMAC (NIRS) and is close to the value predicted by the TPS (2.5). Also, this value is slightly higher than the one measured by the TEPC, this is due to the much higher spatial resolution of SOI microdosimeter allowing for the elimination of the volume averaging effect. The peak value of the RBE 10 for spot pencil beam was about 2.4, this is slightly less than the value for the broad‐beam, which could be explained by less contribution of scattering in the distal part of the SOBP.…”

Section: Discussionmentioning

confidence: 72%

Study on the RBE estimation for carbon beam scanning irradiation using a solid‐state microdosimeter

et al. 2019

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Purpose The purpose of this study was to study the field size effect on the estimated Relative Biological Effectiveness (RBE) for carbon scanning beam irradiation. Methods A silicon‐on‐insulator (SOI) microdosimeter system developed by the Centre for Medical Radiation Physics, University of Wollongong, Australia, was used for lineal‐energy measurements (microdosimetric quantity). The RBE values were derived based on the modified microdosimetric kinetic model (MKM) at different depths in a water phantom in the scanning carbon beam for various scanned areas. Results Our study shows that the difference in RBE values derived from the SOI microdosimeter measurements with the MKM model and from the Treatment Planning System (TPS). The difference of the RBE values is within 6.5 % at the peak point of the spread‐out Bragg Peak (SOBP) region. Compared to the spot‐beam, RBE values obtained in the scanned‐beam with a larger scanned area of 1.0 × 1.0 cm2 have better agreement with which estimated by the TPS. Conclusions This study shows the possibility of using the SOI microdosimeter system as a quality assurance (QA) tool for RBE evaluation in carbon‐pencil beam scanning radiotherapy.

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3D silicon microdosimetry and RBE study using ¹²C ion of different energies

Cited by 11 publications

References 6 publications

Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid‐state microdosimeter

Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid‐state microdosimeter

Microdosimetric measurements of a clinical proton beam with micrometer‐sized solid‐state detector

Study on the RBE estimation for carbon beam scanning irradiation using a solid‐state microdosimeter

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3D silicon microdosimetry and RBE study using 12C ion of different energies

Cited by 11 publications

References 6 publications

Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid‐state microdosimeter

Characterization of proton pencil beam scanning and passive beam using a high spatial resolution solid‐state microdosimeter

Microdosimetric measurements of a clinical proton beam with micrometer‐sized solid‐state detector

Study on the RBE estimation for carbon beam scanning irradiation using a solid‐state microdosimeter

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3D silicon microdosimetry and RBE study using ¹²C ion of different energies