2022
DOI: 10.1007/s10856-022-06702-2
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3D scaffolds of caprolactone/chitosan/polyvinyl alcohol/hydroxyapatite stabilized by physical bonds seeded with swine dental pulp stem cell for bone tissue engineering

Abstract: Bone Regeneration represents a clinical need, related to bone defects such as congenital anomalies, trauma with bone loss, and/or some pathologies such as cysts or tumors This is why a polymeric biomaterial that mimics the osteogenic composition and structure represents a high potential to face this problem. The method of obtaining these materials was first to prepare a stabilized hydrogel by means of physical bonds and then to make use of the lyophilization technique to obtain the 3D porous scaffolds with tem… Show more

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Cited by 7 publications
(5 citation statements)
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References 52 publications
(32 reference statements)
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“…An additional observation relative to the increase in crosslinking points was the reduction of the total porosity calculated for PLGA@CBD10.0% compared with the control hydrogel (Table 1 ). Lower porosity also reduced the swelling ability of hydrogels, as demonstrated in the literature [ 46 ]. However, the PLGA@CBD hydrogels maintained a high porosity (>50%) providing adequate fluid flow to supply nutrients, bioactive compounds, growth factors and ensure the removal of the degradation by-products [ 39 , 47 ].…”
Section: Discussionsupporting
confidence: 57%
See 1 more Smart Citation
“…An additional observation relative to the increase in crosslinking points was the reduction of the total porosity calculated for PLGA@CBD10.0% compared with the control hydrogel (Table 1 ). Lower porosity also reduced the swelling ability of hydrogels, as demonstrated in the literature [ 46 ]. However, the PLGA@CBD hydrogels maintained a high porosity (>50%) providing adequate fluid flow to supply nutrients, bioactive compounds, growth factors and ensure the removal of the degradation by-products [ 39 , 47 ].…”
Section: Discussionsupporting
confidence: 57%
“…Degradation was comparable in both hydrogels. The degradation rate observed could provide the time necessary for primary proliferation, migration, and cell adhesion [ 44 , 46 , 49 ]. This may favor the action of CBD in increasing cellular migration dose-dependently in the first hours of contact with cell lineages similar to those of human osteoblasts [ 28 ].…”
Section: Discussionmentioning
confidence: 99%
“…In that system, PCL as a coating component improved the brittleness and low strength of the HA scaffold, while the particles in the coating improved the osteoconductivity and bioactivity of the coating layer. In addition, there are multicomponent biocomposites, including PDLLA/PCL/HA [377], PLLA/PCL/HA [378], FA-HA/PCL [379], chitosan/PCL/PVA/HA [380], magnetic PCL/Fe-doped HA [381], supramolecular PCL/functionalized HA [382,383], Cu 2 O@CuFeS 2 /HA/chitosan [384], etc. In November 2023, results of the first clinical case of the Ilizarov method of bone reconstruction by means of a bioactive and degradable intramedullary HA/PCL biocomposite implant were published [385].…”
Section: Apatite-based Formulationsmentioning
confidence: 99%
“…Cross-linking agents may affect the biological properties of the CSbased scaffolds. Using ammonium hydroxide to generate physical entanglements and prepare scaffolds had been proved to be non-cytotoxic [107]. Bioglass/chitosan/alginate (BCA) composite scaffolds prepared by the freeze-drying method have potential applications in BTE.…”
Section: Mineralized Cs Scaffolds With Other Organic Componentsmentioning
confidence: 99%