3D scaffolds coated with nanofibers displaying bactericidal activity for bone tissue applications

Sá, Kevin Domingos de; Figueira, Daniela Sofia Rodrigues; Miguel, Sónia P.; Correia, Tiago Ruivo; Silva, Abílio P.; Correia, Ilídio J.

doi:10.1080/00914037.2016.1236338

Cited by 8 publications

(6 citation statements)

References 77 publications

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“…Moreover, the swelling of CH involves the protonation of amine groups and mechanical relaxation of the coiled CH chains [34]. This swelling behaviour is in agreement with that of other 3D printed scaffolds prepared using polymeric materials and TCP reported in the literature [5,35].…”

Section: Evaluation Of the Swelling Profile Of The 3d Scaffoldssupporting

confidence: 87%

“…In turn, the macromolecular chains of the Gel are easily hydrolysed in the presence of water, due to their hydrophilic character [49]. The TCP suffers degradation mediated by cells and its products are naturally metabolized during the resorption bone process [35].…”

Section: Characterization Of Enzymatic Degradation Profile Of the Sca...mentioning

confidence: 99%

“…S6). Such results can be explained by the presence of the CH in all scaffolds' formulations, which is widely described in the literature as a polymer with antibacterial activity [17,18,35]. CH can disturb the bacterial growth through the interaction of its positively charged amine groups with the electronegative residues present at bacterial cell wall surface, which increase cell wall permeability and, subsequently, the leakage of intracellular constituents, leading to dissipation of ionic gradients within the bacteria.…”

Section: Evaluation Of the Bactericidal Activity Of The Scaffoldsmentioning

confidence: 99%

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Green reduced graphene oxide functionalized 3D printed scaffolds for bone tissue regeneration

Cabral

Miguel

Melo‐Diogo

et al. 2019

Carbon

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Section: Evaluation Of the Swelling Profile Of The 3d Scaffoldssupporting

confidence: 87%

Section: Characterization Of Enzymatic Degradation Profile Of the Sca...mentioning

confidence: 99%

Section: Evaluation Of the Bactericidal Activity Of The Scaffoldsmentioning

confidence: 99%

See 1 more Smart Citation

Green reduced graphene oxide functionalized 3D printed scaffolds for bone tissue regeneration

Cabral

Miguel

Melo‐Diogo

et al. 2019

Carbon

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“…Taking into account the limited capacity of bone tissue to fully reconstruct or replace severe defects, the development of novel and performance-enhanced implants is required. Thus, new pathways were used to stimulate bone regeneration and also to prevent the side effects correlated with therapeutics currently used in the clinic [ 214 ].…”

Section: Silver Nanoparticles For Bone Healingmentioning

confidence: 99%

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

et al. 2018

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During the past few years, silver nanoparticles (AgNPs) became one of the most investigated and explored nanotechnology-derived nanostructures, given the fact that nanosilver-based materials proved to have interesting, challenging, and promising characteristics suitable for various biomedical applications. Among modern biomedical potential of AgNPs, tremendous interest is oriented toward the therapeutically enhanced personalized healthcare practice. AgNPs proved to have genuine features and impressive potential for the development of novel antimicrobial agents, drug-delivery formulations, detection and diagnosis platforms, biomaterial and medical device coatings, tissue restoration and regeneration materials, complex healthcare condition strategies, and performance-enhanced therapeutic alternatives. Given the impressive biomedical-related potential applications of AgNPs, impressive efforts were undertaken on understanding the intricate mechanisms of their biological interactions and possible toxic effects. Within this review, we focused on the latest data regarding the biomedical use of AgNP-based nanostructures, including aspects related to their potential toxicity, unique physiochemical properties, and biofunctional behaviors, discussing herein the intrinsic anti-inflammatory, antibacterial, antiviral, and antifungal activities of silver-based nanostructures.

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“…Various studies also were carried out to understand acrylic cement’s clinical potential and feasibility with AgNPs. The acrylic cement modification with AgNPs was explored broadly, but it lacks material characteristics and mechanical properties [ 191 , 192 , 193 , 194 ].…”

Section: Silver Nanoparticles and Antibacterial Activitymentioning

confidence: 99%

Silver Nanoparticles: Bactericidal and Mechanistic Approach against Drug Resistant Pathogens

et al. 2023

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This review highlights the different modes of synthesizing silver nanoparticles (AgNPs) from their elemental state to particle format and their mechanism of action against multidrug-resistant and biofilm-forming bacterial pathogens. Various studies have demonstrated that the AgNPs cause oxidative stress, protein dysfunction, membrane disruption, and DNA damage in bacteria, ultimately leading to bacterial death. AgNPs have also been found to alter the adhesion of bacterial cells to prevent biofilm formation. The benefits of using AgNPs in medicine are, to some extent, counter-weighted by their toxic effect on humans and the environment. In this review, we have compiled recent studies demonstrating the antibacterial activity of AgNPs, and we are discussing the known mechanisms of action of AgNPs against bacterial pathogens. Ongoing clinical trials involving AgNPs are briefly presented. A particular focus is placed on the mechanism of interaction of AgNPs with bacterial biofilms, which are a significant pathogenicity determinant. A brief overview of the use of AgNPs in other medical applications (e.g., diagnostics, promotion of wound healing) and the non-medical sectors is presented. Finally, current drawbacks and limitations of AgNPs use in medicine are discussed, and perspectives for the improved future use of functionalized AgNPs in medical applications are presented.

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3D scaffolds coated with nanofibers displaying bactericidal activity for bone tissue applications

Cited by 8 publications

References 77 publications

Green reduced graphene oxide functionalized 3D printed scaffolds for bone tissue regeneration

Green reduced graphene oxide functionalized 3D printed scaffolds for bone tissue regeneration

Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

Silver Nanoparticles: Bactericidal and Mechanistic Approach against Drug Resistant Pathogens

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