Green reduced graphene oxide functionalized 3D printed scaffolds for bone tissue regeneration

Cabral, Cátia S.D.; Miguel, Sónia P.; Melo‐Diogo, Duarte de; Louro, Ricardo O.; Correia, Ilídio J.

doi:10.1016/j.carbon.2019.01.100

Cited by 56 publications

(52 citation statements)

References 61 publications

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“…GO was added to this blend and reduced to RGO in situ by L-ascorbic acid treatment. When comparing mechanical properties of scaffolds incorporating GO or RGO they found the latter to better mimic bone Young modulus, thus their scaffold might be useful as a temporary support for bone regeneration [ 79 ].…”

Section: Graphene-based Scaffoldsmentioning

confidence: 99%

Graphene-Based Scaffolds for Regenerative Medicine

et al. 2021

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Leading-edge regenerative medicine can take advantage of improved knowledge of key roles played, both in stem cell fate determination and in cell growth/differentiation, by mechano-transduction and other physicochemical stimuli from the tissue environment. This prompted advanced nanomaterials research to provide tissue engineers with next-generation scaffolds consisting of smart nanocomposites and/or hydrogels with nanofillers, where balanced combinations of specific matrices and nanomaterials can mediate and finely tune such stimuli and cues. In this review, we focus on graphene-based nanomaterials as, in addition to modulating nanotopography, elastic modulus and viscoelastic features of the scaffold, they can also regulate its conductivity. This feature is crucial to the determination and differentiation of some cell lineages and is of special interest to neural regenerative medicine. Hereafter we depict relevant properties of such nanofillers, illustrate how problems related to their eventual cytotoxicity are solved via enhanced synthesis, purification and derivatization protocols, and finally provide examples of successful applications in regenerative medicine on a number of tissues.

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Section: Graphene-based Scaffoldsmentioning

confidence: 99%

Graphene-Based Scaffolds for Regenerative Medicine

et al. 2021

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“…Sometimes, they are incorporated into a ceramic matrix to improve their toughness and processability. Both synthetic [ 68 , 69 ] and natural [ 70 ] polymers are used for this purpose.…”

Section: Nanomaterials For Scaffoldsmentioning

confidence: 99%

“…Many studies have reported the use of reduced graphene oxide (rGO) instead of GO in the preparation of nanocomposites [ 70 , 100 , 101 ]. The reduction in GO leads to the elimination of most oxygen-containing functional groups, thus the sp 2 structure and, therefore, electrical conductivity are partially restored; consequently, rGO reaches excellent electrical conductivity and high mobility [ 96 , 102 , 103 ].…”

Section: Carbon-based Nanomaterialsmentioning

confidence: 99%

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Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

et al. 2020

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Bone possesses an inherent capacity to fix itself. However, when a defect larger than a critical size appears, external solutions must be applied. Traditionally, an autograft has been the most used solution in these situations. However, it presents some issues such as donor-site morbidity. In this context, porous biodegradable scaffolds have emerged as an interesting solution. They act as external support for cell growth and degrade when the defect is repaired. For an adequate performance, these scaffolds must meet specific requirements: biocompatibility, interconnected porosity, mechanical properties and biodegradability. To obtain the required porosity, many methods have conventionally been used (e.g., electrospinning, freeze-drying and salt-leaching). However, from the development of additive manufacturing methods a promising solution for this application has been proposed since such methods allow the complete customisation and control of scaffold geometry and porosity. Furthermore, carbon-based nanomaterials present the potential to impart osteoconductivity and antimicrobial properties and reinforce the matrix from a mechanical perspective. These properties make them ideal for use as nanomaterials to improve the properties and performance of scaffolds for bone tissue engineering. This work explores the potential research opportunities and challenges of 3D printed biodegradable composite-based scaffolds containing carbon-based nanomaterials for bone tissue engineering applications.

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“…Scaffolds comprised of chitosan, gelatin, TCP and graphene oxide are prepared via 3D-printing and subsequently treated with l-ascorbic acid to reduce graphene oxide and thus enhance mechanical and osteogenic properties. Besides enhanced ALP-activity of human osteoblast cells and Ca-deposition on the scaffolds, scaffolds showed antimicrobial activity towards S. aureus and E. coli without a negative effect on viability and proliferation of osteoblasts [151]. Chitosan-graphene oxide hybrid scaffolds have also been developed by directional freezing followed by lyophilization to create a porous and aligned 3D morphology.…”

Section: Miscellaneous Additivesmentioning

confidence: 99%

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

et al. 2019

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Bone tissue engineering is an ever-changing, rapidly evolving, and highly interdisciplinary field of study, where scientists try to mimic natural bone structure as closely as possible in order to facilitate bone healing. New insights from cell biology, specifically from mesenchymal stem cell differentiation and signaling, lead to new approaches in bone regeneration. Novel scaffold and drug release materials based on polysaccharides gain increasing attention due to their wide availability and good biocompatibility to be used as hydrogels and/or hybrid components for drug release and tissue engineering. This article reviews the current state of the art, recent developments, and future perspectives in polysaccharide-based systems used for bone regeneration.

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Green reduced graphene oxide functionalized 3D printed scaffolds for bone tissue regeneration

Cited by 56 publications

References 61 publications

Graphene-Based Scaffolds for Regenerative Medicine

Graphene-Based Scaffolds for Regenerative Medicine

Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

Polysaccharide-Based Systems for Targeted Stem Cell Differentiation and Bone Regeneration

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