3D scaffolding of fast photocurable polyurethane for soft tissue engineering by stereolithography: Influence of materials and geometry on growth of fibroblast cells

Farzan, Afsoon; Borandeh, Sedigheh; Ezazi, Nazanin Zanjanizadeh; Lipponen, Sami; Santos, Hélder A.; Seppälä, Jukka

doi:10.1016/j.eurpolymj.2020.109988

Cited by 44 publications

(43 citation statements)

References 67 publications

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“…In some cases, post-curing with a UV oven can be used to increase the mechanical strength of the object [ 54 ]. In the medical field, stereolithographic 3D printing is mainly used in tissue engineering [ 55 , 56 , 57 , 58 ] and in the fabrication of implantable devices [ 59 , 60 ]. However, applications in the pharmaceutical field are still limited.…”

Section: 3d-printing Techniquesmentioning

confidence: 99%

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

et al. 2021

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The aim of this review is to present the factors influencing the mechanical properties of 3D-printed oral dosage forms. It also explores how it is possible to use specific excipients and printing parameters to maintain the structural integrity of printed drug products while meeting the needs of patients. Three-dimensional (3D) printing is an emerging manufacturing technology that is gaining acceptance in the pharmaceutical industry to overcome traditional mass production and move toward personalized pharmacotherapy. After continuous research over the last thirty years, 3D printing now offers numerous opportunities to personalize oral dosage forms in terms of size, shape, release profile, or dose modification. However, there is still a long way to go before 3D printing is integrated into clinical practice. 3D printing techniques follow a different process than traditional oral dosage from manufacturing methods. Currently, there are no specific guidelines for the hardness and friability of 3D printed solid oral dosage forms. Therefore, new regulatory frameworks for 3D-printed oral dosage forms should be established to ensure that they meet all appropriate quality standards. The evaluation of mechanical properties of solid dosage forms is an integral part of quality control, as tablets must withstand mechanical stresses during manufacturing processes, transportation, and drug distribution as well as rough handling by the end user. Until now, this has been achieved through extensive pre- and post-processing testing, which is often time-consuming. However, computational methods combined with 3D printing technology can open up a new avenue for the design and construction of 3D tablets, enabling the fabrication of structures with complex microstructures and desired mechanical properties. In this context, the emerging role of computational methods and artificial intelligence techniques is highlighted.

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Section: 3d-printing Techniquesmentioning

confidence: 99%

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

et al. 2021

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“…Used to make ceramic, metal, and metal/ceramic composite part; used for precise control of scaffold structure at the micron level [24] Variation in temperature affects extrusion pressure, including nozzle length-to-diameter ratio, and the extrusion velocity [34] Stereolithography High resolution, uniformity in pore connectivity [24] Requires a massive number of monomers and post-polymerization treatment to improve monomer conversion [35,36] Apart from the conventional fabrication technique, 3D bioprinting involving the use of computer-controlled deposition of cells into precise 3D geometrical patterns has shown promising accuracy in cell delivery to replicate natural skin anisotropy [35]. Tarassoli et al (2018) describe two main approaches to arranging cells in 3D patterns.…”

Section: Conventional Fabrication Techniques Electrospinningmentioning

confidence: 99%

Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review

2021

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Skin tissue engineering has made remarkable progress in wound healing treatment with the advent of newer fabrication strategies using natural/synthetic polymers and stem cells. Stem cell therapy is used to treat a wide range of injuries and degenerative diseases of the skin. Nevertheless, many related studies demonstrated modest improvement in organ functions due to the low survival rate of transplanted cells at the targeted injured area. Thus, incorporating stem cells into biomaterial offer niches to transplanted stem cells, enhancing their delivery and therapeutic effects. Currently, through the skin tissue engineering approach, many attempts have employed biomaterials as a platform to improve the engraftment of implanted cells and facilitate the function of exogenous cells by mimicking the tissue microenvironment. This review aims to identify the limitations of stem cell therapy in wound healing treatment and potentially highlight how the use of various biomaterials can enhance the therapeutic efficiency of stem cells in tissue regeneration post-implantation. Moreover, the review discusses the combined effects of stem cells and biomaterials in in vitro and in vivo settings followed by identifying the key factors contributing to the treatment outcomes. Apart from stem cells and biomaterials, the role of growth factors and other cellular substitutes used in effective wound healing treatment has been mentioned. In conclusion, the synergistic effect of biomaterials and stem cells provided significant effectiveness in therapeutic outcomes mainly in wound healing improvement.

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“…[ 53 ] Farzan et al. [ 101 ] developed a fast photocurable polyurethane (PU) for SLA to fabricate complex 3D scaffolds. The parts produced with their resin showed tensile stress and strain at break of 3.33 MPa and 145%, respectively.…”

Section: Biomaterialsmentioning

confidence: 99%

“…Moreover, as shown in Figure , their scaffolds samples had higher cell viability and proliferation when compared with other materials, and an in vitro hydrolytic degradation of 18% after 6 months (without signals of any cytotoxicity effect). [ 101 ] Weisgarb et al. [ 38 ] developed a biocompatible resin using poly(trimethylene‐carbonate) (PTMC) for printing high porous scaffolds using a 2PP machine.…”

Section: Biomaterialsmentioning

confidence: 99%

Nanomaterials for 3D Printing of Polymers via Stereolithography: Concept, Technologies, and Applications

Rosa

Rosace

2021

Macro Materials & Eng

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Stereolithography (SLA) is an additive manufacturing method with one of the highest accuracies (down to 100 nm) of all solid freeform techniques and has been used in various areas, such as medicine, automotive, aerospace, electronics, and others. However, most resins available nowadays are derived from petroleum. Its toxicity, low biocompatibility, and growing environmental concerns are limiting its application. This review discusses the development of biobased and biocompatible materials for different SLA processes as well as the usage of nanocomposites to increase their applicability. A comprehensive overview of the SLA technologies, photopolymerization chemistry, and resin properties are also provided. Finally, various examples using different types of materials are explored, to show the current and future capabilities of the SLA technique.

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3D scaffolding of fast photocurable polyurethane for soft tissue engineering by stereolithography: Influence of materials and geometry on growth of fibroblast cells

Cited by 44 publications

References 67 publications

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

3D-Printed Oral Dosage Forms: Mechanical Properties, Computational Approaches and Applications

Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review

Nanomaterials for 3D Printing of Polymers via Stereolithography: Concept, Technologies, and Applications

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