3D printing: potential clinical applications for personalised solid dose medications

Krueger, Liam; Miles, Jared A.; Steadman, Kathryn J.; Kumeria, Tushar; Freeman, Chris; Popat, Amirali

doi:10.5694/mja2.51381

Cited by 8 publications

(2 citation statements)

References 10 publications

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“…Unfortunately, they did not focus on the critical issue of acid resistance of drugs in the stomach. In addition, blank granules of excipient (for the studies of API loading, optimizing the ratio of polymer to disintegrant (key material properties, KMP)) in FDM-printing DFs were also successfully developed for IR tablet [ 168 , 169 ].…”

Section: Pharmaceutical Dosage Forms By 3dpmentioning

confidence: 99%

3D printing processes in precise drug delivery for personalized medicine

Peng,

Han,

Tong

et al. 2024

Biofabrication

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With the advent of personalized medicine, the drug delivery system (DDS) will be changed significantly. The development of personalized medicine needs the support of many technologies, among which three-dimensional printing (3DP) technology is a novel formulation-preparing process that creates 3D objects by depositing printing materials layer-by-layer based on the computer-aided design (CAD) method. Compared with traditional pharmaceutical processes, 3DP produces complex drug combinations, personalized dosage, and flexible shape and structure of dosage forms (DFs) on demand. In the future, personalized 3DP drugs may supplement and even replace their traditional counterpart. We systematically introduce the applications of 3DP technologies in the pharmaceutical industry and summarize the virtues and shortcomings of each technique. The release behaviors and control mechanisms of the pharmaceutical DFs with desired structures are also analyzed. Finally, the benefits, challenges, and prospects of 3DP technology to the pharmaceutical industry are discussed.

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Section: Pharmaceutical Dosage Forms By 3dpmentioning

confidence: 99%

3D printing processes in precise drug delivery for personalized medicine

Peng,

Han,

Tong

et al. 2024

Biofabrication

View full text Add to dashboard Cite

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“…Though liquid dose and splitable tablets are available to circumvent the abovementioned issue, the inaccuracy cause due to improper sparing and approximate measurement of tablets and solutions respectively again results in needless side effects inside the body (Walsh et al 2022). For these pertaining issues, the advent of 3D printing in the pharmaceutical field was regarded as a great boon for designing the drug delivery systems to provide exclusive treatment for the individuals (Krueger et al 2022). The process of 3D printing has revolutionized the personalized therapy, with its numerous advantages like design flexibility, accurate and required drug loading etc (Aimar et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Semisolid extrusion 3D printing of Dolutegravir-Chitosan nanoparticles laden polymeric buccal films: personalized solution for pediatric treatment

Krishnan,

Durai,

Veluri

et al. 2024

Biomed. Mater.

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In this work, the semi-solid extrusion (SSE) 3D printing process was utilized to incorporate anti-HIV drug Dolutegravir and its nanoparticles into the buccal film (BF) that was fabricated using the developed polymer ink. The composite made of polyvinyl alcohol (PVA) and sodium alginate (SA) was processed into a 3D printing polymer ink with optimum viscosity (9587 ± 219 cP) needed for the seamless extrusion through the nozzle of the 3D printer. The formulated BFs were assessed for its physical properties like weight (0.414 ± 0.3 g), thickness (1.54 ± 0.02 mm), swelling index (18.5 ± 0.91 %), and mucoadhesiveness strength (0.165 ± 0.09 N) etc., The structural integrity and the surface morphology of the developed BFs were investigated by SEM analysis. The chemical stability and the solid-state nature of the drug in the BFs were assessed by FTIR and XRD analysis respectively. Further the BFs were assessed for drug dissolution in-vitro and ex-vivo, to study the effect of polymer composition and printing condition on the dissolution profile of the drug in the simulated salivary fluid. The results demonstrated that the developed PVA based polymer ink for 3D printing utilizing pressure is a versatile approach in the context of manufacturing mucoadhesive buccal films customized in terms of shape and the amount of drug loaded.

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